TRANS-2-(4-(TRIFLUOROMETHYL)PHENYL)-

Base Information

• Chemical Name: TRANS-2-(4-(TRIFLUOROMETHYL)PHENYL)-
• CAS No.: 352525-91-8
• Molecular Formula: C₉H₈BF₃O₂
• Molecular Weight: 215.968
• Hs Code.: 2931900090
• Mol file: 352525-91-8.mol

Synonyms:Boronicacid, [(1E)-2-[4-(trifluoromethyl)phenyl]ethenyl]- (9CI);[(E)-2-[4-(Trifluoromethyl)phenyl]ethenyl]boronic acid

Chemical Property of TRANS-2-(4-(TRIFLUOROMETHYL)PHENYL)-

Chemical Property:

• Vapor Pressure: 0.000304mmHg at 25°C
• Melting Point: 204-210 °C(lit.)
• Refractive Index: 1.507
• Boiling Point: 307.9°C at 760 mmHg
• Flash Point: 140°C
• PSA: 40.46000
• Density: 1.313g/cm³
• LogP: 1.73060

Purity/Quality:

97% ^*data from raw suppliers

trans-2-[4-(Trifluoromethyl)phenyl]vinylboronic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: trans-2-[4-(Trifluoromethyl)phenyl]vinylboronic Acid is used in preparation of novel chromane, isochromane, thiochromane, or tetrahydroquinoline derivatives as glucosylceramide synthase (GCS) inhibitors. Reactant for:Microwave-assisted Suzuki-Miyaura cross-couplingCobalt-catalyzed coupling reactionsPreparation of vinylic MIDA boronatesSynthesis of C2-aryl pyrrolobenzodiazepine antitumor agentsSuzuki-Miyaura cross-coupling reaction

Technology Process of TRANS-2-(4-(TRIFLUOROMETHYL)PHENYL)-

There total 6 articles about TRANS-2-(4-(TRIFLUOROMETHYL)PHENYL)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Trimethyl borate (121-43-7,63156-11-6) + C9H6BrF3Mg → trans-2-[4-(trifluoromethyl)phenyl]vinylboronic acid (352525-91-8)

Guidance literature:

C₉H₆BrF₃Mg; With lithium chloride; In tetrahydrofuran; diethyl ether; at -78 ℃; Inert atmosphere;

Trimethyl borate; In tetrahydrofuran; diethyl ether; at 20 ℃; Inert atmosphere;

DOI:10.3390/molecules26061615

Reference yield:

4-trifluoromethylphenylacetylene (705-31-7) → 4-trifluoromethylstyrenylboronic acid (851660-03-2,352525-91-8)

Guidance literature:

4-trifluoromethylphenylacetylene; With benzo[1,3,2]dioxaborole; at 70 ℃; for 4h;

With water; at 20 ℃; for 9h;

DOI:10.1021/ol800829q

Reference yield:

4-trifluoromethylphenylacetylene (705-31-7) + benzo[1,3,2]dioxaborole (274-07-7) → trans-2-[4-(trifluoromethyl)phenyl]vinylboronic acid (352525-91-8)

Guidance literature:

4-trifluoromethylphenylacetylene; benzo[1,3,2]dioxaborole; at 0 - 70 ℃; for 1h; Inert atmosphere;

With water; Inert atmosphere; Heating;

DOI:10.1021/acs.orglett.5b02954

upstream raw materials:

4-trifluoromethylphenylacetylene

benzo[1,3,2]dioxaborole

(E)-4,4,5,5-tetramethyl-2-(4-trifluoromethylphenyl-vin-1-yl)-1,3,2-dioxaborolane

Trimethyl borate

Downstream raw materials:

C₂₃H₂₀F₃NO₂S

3,4-bis(benzyloxy)-6-[(E)-2-[4-(trifluoromethyl)phenyl]-ethenyl]pyridazine

C₁₉H₁₈F₃NO₄S₂

4-amino-1-(3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-(4-(trifluoromethyl)styryl)pyrimidin-2(1H)-one