Technology Process of (2R,3S,6R)-6-<2-(benzyloxy)-1(S)-methyl>ethyl-3,6-dihydro-3-methyl-2-(1-oxopropyl)-2H-pyran
There total 11 articles about (2R,3S,6R)-6-<2-(benzyloxy)-1(S)-methyl>ethyl-3,6-dihydro-3-methyl-2-(1-oxopropyl)-2H-pyran which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) O3; 2.) Me2S / 1.) methylene dichloride, -78 deg C; 2.) room temp., 2 h
2: diethyl ether / 2 h / -78 °C
3: 99 percent / 1.) trifluoroacetic acid / benzene / 3 h / Heating
5: 1.) i-Bu2AlH / 1.) diethyl ether, THF, -78 deg C, 1.5 h; 2.) THF, room temp., 2 h
6: 93 percent / H2Cr2O7 / acetone; propan-2-ol; H2O / 0.25 h / 25 °C
With
dimethylsulfide; dichromic acid; diisobutylaluminium hydride; ozone; trifluoroacetic acid;
In
diethyl ether; water; isopropyl alcohol; acetone; benzene;
DOI:10.1016/S0040-4020(01)90568-X
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 97 percent / NaH / tetrahydrofuran / 12 h / Heating
2: 88 percent / DMAP, DCC / CH2Cl2 / 3 h / 25 °C
3: 1.) O3; 2.) Me2S / 1.) methylene dichloride, -78 deg C; 2.) room temp., 2 h
4: diethyl ether / 2 h / -78 °C
5: 99 percent / 1.) trifluoroacetic acid / benzene / 3 h / Heating
7: 1.) i-Bu2AlH / 1.) diethyl ether, THF, -78 deg C, 1.5 h; 2.) THF, room temp., 2 h
8: 93 percent / H2Cr2O7 / acetone; propan-2-ol; H2O / 0.25 h / 25 °C
With
dmap; dimethylsulfide; dichromic acid; sodium hydride; diisobutylaluminium hydride; ozone; dicyclohexyl-carbodiimide; trifluoroacetic acid;
In
tetrahydrofuran; diethyl ether; dichloromethane; water; isopropyl alcohol; acetone; benzene;
DOI:10.1016/S0040-4020(01)90568-X
