7-Chloro-3,3-dimethyl-1-(2-methyl-benzoyl)-2,3-dihydro-1H-quinolin-4-one

Base Information

• Chemical Name: 7-Chloro-3,3-dimethyl-1-(2-methyl-benzoyl)-2,3-dihydro-1H-quinolin-4-one
• CAS No.: 210419-90-2
• Molecular Formula: C₁₉H₁₈ClNO₂
• Molecular Weight: 327.81
• Mol file: 210419-90-2.mol

Synonyms:7-Chloro-3,3-dimethyl-1-(2-methyl-benzoyl)-2,3-dihydro-1H-quinolin-4-one

Chemical Property of 7-Chloro-3,3-dimethyl-1-(2-methyl-benzoyl)-2,3-dihydro-1H-quinolin-4-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-Chloro-3,3-dimethyl-1-(2-methyl-benzoyl)-2,3-dihydro-1H-quinolin-4-one

There total 1 articles about 7-Chloro-3,3-dimethyl-1-(2-methyl-benzoyl)-2,3-dihydro-1H-quinolin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

7-chloro-2,3-dihydro-1-(2-methyl-benzoyl)-4(1H)-quinolinone (114417-14-0) + methyl iodide (74-88-4) → 7-Chloro-3,3-dimethyl-1-(2-methyl-benzoyl)-2,3-dihydro-1H-quinolin-4-one (210419-90-2) + 7-Chloro-3-methyl-1-(2-methyl-benzoyl)-2,3-dihydro-1H-quinolin-4-one (210419-89-9)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; at -75 - 0 ℃; for 2h;

DOI:10.1016/S0223-5234(98)80061-5

Reference yield: 90.0%

7-Chloro-3,3-dimethyl-1-(2-methyl-benzoyl)-2,3-dihydro-1H-quinolin-4-one (210419-90-2) → 7-Chloro-3,3-dimethyl-1-(2-methyl-benzoyl)-2,3-dihydro-1H-quinolin-4-one oxime

Guidance literature:

With pyridine; hydroxylamine hydrochloride; In ethanol; for 2h; Heating;

DOI:10.1016/S0223-5234(98)80061-5

Reference yield:

7-Chloro-3,3-dimethyl-1-(2-methyl-benzoyl)-2,3-dihydro-1H-quinolin-4-one (210419-90-2) → 7-chloro-2,3-dihydro-3,3-dimethyl-1-(2-methylbenzoyl)-4(1H)-quinolinone 4-oxime-O-sulfonic acid potassium salt

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / NH₂OH*HCl, pyridine / ethanol / 2 h / Heating

2: 1) pyridine*SO₃, 2) aq. K₂CO₃ / 1) CH₂Cl₂, r.t., 24 h, 2) MeOH

With pyridine; hydroxylamine hydrochloride; sulfur trioxide pyridine complex; potassium carbonate; In ethanol;

DOI:10.1016/S0223-5234(98)80061-5

upstream raw materials:

7-chloro-2,3-dihydro-1-(2-methyl-benzoyl)-4(1H)-quinolinone

methyl iodide