N,N-dimethyl-2-anisyl-2-hydroxy-2-phenylthioacetamide

Base Information

• Chemical Name: N,N-dimethyl-2-anisyl-2-hydroxy-2-phenylthioacetamide
• CAS No.: 111359-27-4
• Molecular Formula: C₁₇H₁₉NO₂S
• Molecular Weight: 301.409
• Mol file: 111359-27-4.mol

Synonyms:N,N-dimethyl-2-anisyl-2-hydroxy-2-phenylthioacetamide

Chemical Property of N,N-dimethyl-2-anisyl-2-hydroxy-2-phenylthioacetamide

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of N,N-dimethyl-2-anisyl-2-hydroxy-2-phenylthioacetamide

There total 1 articles about N,N-dimethyl-2-anisyl-2-hydroxy-2-phenylthioacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

4-Methoxybenzophenone (611-94-9) + N,N-dimethylthioformamide (758-16-7) → N,N-dimethyl-2-anisyl-2-hydroxy-2-phenylthioacetamide (111359-27-4)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; -78 deg C, then warm to Rt, over 3 h;

Reference yield: 96.0%

N,N-dimethyl-2-anisyl-2-hydroxy-2-phenylthioacetamide (111359-27-4) → 2-dimethylamino-6-methoxy-3-phenylbenzothiophene (111359-31-0)

Guidance literature:

With methanesulfonic acid; In dichloromethane; at 0 ℃; for 0.166667h;

Reference yield:

N,N-dimethyl-2-anisyl-2-hydroxy-2-phenylthioacetamide (111359-27-4) → N,N-dimethyl-2-anisyl-2-phenylthioacetamide-2-yl cation (111359-36-5)

Guidance literature:

With chlorosulfonic acid; In dichloromethane-d2; at -95 ℃; Product distribution; investigation of the carbocation formation from various α-hydroxy-α-aryl thioacetamides; substituent effect on the cation formation is dicussed;

upstream raw materials:

4-Methoxybenzophenone

N,N-dimethylthioformamide

Downstream raw materials:

2-dimethylamino-6-methoxy-3-phenylbenzothiophene

N,N-dimethyl-2-anisyl-2-phenylthioacetamide-2-yl cation

Refernces