1-hydroxy-2-(3',5'-di-O-acetyl-2'-deoxy-β-D-ribofuranosyl)benzene

Base Information

• Chemical Name: 1-hydroxy-2-(3',5'-di-O-acetyl-2'-deoxy-β-D-ribofuranosyl)benzene
• CAS No.: 479582-36-0
• Molecular Formula: C₁₅H₁₈O₆
• Molecular Weight: 294.304
• Mol file: 479582-36-0.mol

Synonyms:1-hydroxy-2-(3',5'-di-O-acetyl-2'-deoxy-β-D-ribofuranosyl)benzene

Chemical Property of 1-hydroxy-2-(3',5'-di-O-acetyl-2'-deoxy-β-D-ribofuranosyl)benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-hydroxy-2-(3',5'-di-O-acetyl-2'-deoxy-β-D-ribofuranosyl)benzene

There total 1 articles about 1-hydroxy-2-(3',5'-di-O-acetyl-2'-deoxy-β-D-ribofuranosyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

1,3,5-tri-O-acetyl-2-deoxyribose (4594-52-9,96291-74-6,96291-75-7) + phenol (108-95-2,27073-41-2) → 1-hydroxy-2-(3',5'-di-O-acetyl-2'-deoxy-β-D-ribofuranosyl)benzene (479582-36-0)

Guidance literature:

With bis(cyclopentadienyl)hafnium dichloride; 4 A molecular sieve; silver perchlorate; In dichloromethane; at -78 - -5 ℃; for 4h;

DOI:10.1021/jm020193w

Reference yield: 76.0%

1-hydroxy-2-(3',5'-di-O-acetyl-2'-deoxy-β-D-ribofuranosyl)benzene (479582-36-0) → 1-hydroxy-2-(2'-deoxy-β-D-ribofuranosyl)benzene (479582-28-0)

Guidance literature:

With ammonium hydroxide; In methanol; at 20 ℃; for 5h;

DOI:10.1021/jm020193w

Reference yield:

1-hydroxy-2-(3',5'-di-O-acetyl-2'-deoxy-β-D-ribofuranosyl)benzene (479582-36-0) → 1-hydroxy-2-(2'-deoxy-β-D-ribofuranosyl)benzene 5'-triphosphate

Guidance literature:

Multi-step reaction with 2 steps

1.1: 76 percent / aq.NH₃ / methanol / 5 h / 20 °C

2.1: 1,8-bis(dimethylamino)naphthalene; POCl₃; trimethyl phosphate / 3 h / 0 °C

2.2: Bu₃N; tributylammonium pyrophosphate / dimethylformamide / 0.02 h

With trimethyl phosphite; ammonium hydroxide; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; trichlorophosphate; In methanol;

DOI:10.1021/jm020193w

upstream raw materials:

1,3,5-tri-O-acetyl-2-deoxyribose

phenol

Downstream raw materials:

1-hydroxy-2-(2'-deoxy-β-D-ribofuranosyl)benzene