N-(3-(2-((2-methoxy-4-(4-methyl-1-piperazinyl)phenyl)amino)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)-2-propenamide

Base Information

Chemical Name:N-(3-(2-((2-methoxy-4-(4-methyl-1-piperazinyl)phenyl)amino)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)-2-propenamide
CAS No.:1429497-53-9
Molecular Formula:C₂₈H₂₉N₇O₃
Molecular Weight:511.583
Hs Code.:

Synonyms:N-(3-(2-((2-methoxy-4-(4-methyl-1-piperazinyl)phenyl)amino)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)-2-propenamide

Suppliers and Price of N-(3-(2-((2-methoxy-4-(4-methyl-1-piperazinyl)phenyl)amino)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)-2-propenamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(3-(2-((2-methoxy-4-(4-methyl-1-piperazinyl)phenyl)amino)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)-2-propenamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(3-(2-((2-methoxy-4-(4-methyl-1-piperazinyl)phenyl)amino)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)-2-propenamide

There total 13 articles about N-(3-(2-((2-methoxy-4-(4-methyl-1-piperazinyl)phenyl)amino)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)-2-propenamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1429497-81-3
8-(3-aminophenyl)-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one

: 814-68-6,25189-84-8
acryloyl chloride

: 1429497-53-9
N-(3-(2-((2-methoxy-4-(4-methyl-1-piperazinyl)phenyl)amino)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)-2-propenamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 1h;
DOI:10.1039/c5md00208g

Reference yield:

: 68621-88-5
(3-aminophenyl)carbamic acid tert-butyl ester

: 1429497-53-9
N-(3-(2-((2-methoxy-4-(4-methyl-1-piperazinyl)phenyl)amino)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)-2-propenamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 20 - 80 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 13 h / -40 - 0 °C

3.1: manganese(IV) oxide / chloroform / 18 h / 20 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran; 2-methyltetrahydrofuran / 0.17 h / -78 °C

4.2: 3.17 h / -78 - 20 °C

5.1: peracetic acid / dichloromethane; acetic acid / 0 °C

6.1: N-ethyl-N,N-diisopropylamine / tert-butyl alcohol / 21 h / 80 °C

7.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

8.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran; dichloromethane / 2.5 h / 0 °C

With peracetic acid; manganese(IV) oxide; lithium aluminium tetrahydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; 2-methyltetrahydrofuran; dichloromethane; chloroform; acetic acid; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 1363161-16-3
tert-butyl 3-(5-(formyl)-2-(methylmercapto)pyrimidine-4-ylamino)phenylcarbamate

: 1429497-53-9
N-(3-(2-((2-methoxy-4-(4-methyl-1-piperazinyl)phenyl)amino)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)-2-propenamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran; 2-methyltetrahydrofuran / 0.17 h / -78 °C

1.2: 3.17 h / -78 - 20 °C

2.1: peracetic acid / dichloromethane; acetic acid / 0 °C

3.1: N-ethyl-N,N-diisopropylamine / tert-butyl alcohol / 21 h / 80 °C

4.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran; dichloromethane / 2.5 h / 0 °C

With peracetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; 2-methyltetrahydrofuran; dichloromethane; acetic acid; tert-butyl alcohol;