methyl 3-methyl-2-(2-oxo-4-[(5-oxopyrrolidin-2-yl)carbonyl]-3-{[1-(triphenylmethyl)-1H-imidazol-4-yl]methyl}piperazin-1-yl)butanoate

Base Information

Chemical Name:methyl 3-methyl-2-(2-oxo-4-[(5-oxopyrrolidin-2-yl)carbonyl]-3-{[1-(triphenylmethyl)-1H-imidazol-4-yl]methyl}piperazin-1-yl)butanoate
CAS No.:282529-12-8
Molecular Formula:C₃₈H₄₁N₅O₅
Molecular Weight:647.774
Hs Code.:

Synonyms:methyl 3-methyl-2-(2-oxo-4-[(5-oxopyrrolidin-2-yl)carbonyl]-3-{[1-(triphenylmethyl)-1H-imidazol-4-yl]methyl}piperazin-1-yl)butanoate

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Chemical Property of methyl 3-methyl-2-(2-oxo-4-[(5-oxopyrrolidin-2-yl)carbonyl]-3-{[1-(triphenylmethyl)-1H-imidazol-4-yl]methyl}piperazin-1-yl)butanoate

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Technology Process of methyl 3-methyl-2-(2-oxo-4-[(5-oxopyrrolidin-2-yl)carbonyl]-3-{[1-(triphenylmethyl)-1H-imidazol-4-yl]methyl}piperazin-1-yl)butanoate

There total 7 articles about methyl 3-methyl-2-(2-oxo-4-[(5-oxopyrrolidin-2-yl)carbonyl]-3-{[1-(triphenylmethyl)-1H-imidazol-4-yl]methyl}piperazin-1-yl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 98-79-3
L-Pyroglutamic acid

: 282529-10-6
methyl 3-methyl-2-(2-oxo-3-{[1-(triphenylmethyl)-1H-imidazol-4-yl]methyl}piperazin-1-yl)butanoate

: 282529-12-8
methyl 3-methyl-2-(2-oxo-4-[(5-oxopyrrolidin-2-yl)carbonyl]-3-{[1-(triphenylmethyl)-1H-imidazol-4-yl]methyl}piperazin-1-yl)butanoate

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In dichloromethane; at 20 ℃; for 48h;
DOI:10.1002/(SICI)1522-2675(20000412)83:4<722::AID-HLCA722>3.0.CO;2-Z

Reference yield:

: 6306-52-1
L-valine methylester hydrochloride

: 282529-12-8
methyl 3-methyl-2-(2-oxo-4-[(5-oxopyrrolidin-2-yl)carbonyl]-3-{[1-(triphenylmethyl)-1H-imidazol-4-yl]methyl}piperazin-1-yl)butanoate

Guidance literature:: Multi-step reaction with 6 steps

1: 99 percent / BOP; Et₃N / CH₂Cl₂ / 12 h

2: 4-(aminomethyl)piperidine / CHCl₃ / 2 h

3: 93.6 percent / Et₃N / CHCl₃ / 5 h

4: 40 percent / K₂CO₃ / dimethylformamide / 14 h

5: 88.3 percent / K₂CO₃; PhSH / dimethylformamide / 12 h / 20 °C

6: 79 percent / BOP; Et₃N / CH₂Cl₂ / 48 h / 20 °C

With potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; 4-Aminomethylpiperidine; thiophenol; triethylamine; In dichloromethane; chloroform; N,N-dimethyl-formamide; 1: Acylation / 2: deacylation / 3: Acylation / 4: Cyclization / 5: Substitution / 6: Acylation;
DOI:10.1002/(SICI)1522-2675(20000412)83:4<722::AID-HLCA722>3.0.CO;2-Z

Reference yield:

: 109425-51-6
Fmoc-His(Trt)-OH

: 282529-12-8
methyl 3-methyl-2-(2-oxo-4-[(5-oxopyrrolidin-2-yl)carbonyl]-3-{[1-(triphenylmethyl)-1H-imidazol-4-yl]methyl}piperazin-1-yl)butanoate

Guidance literature:: Multi-step reaction with 6 steps

1: 99 percent / BOP; Et₃N / CH₂Cl₂ / 12 h

2: 4-(aminomethyl)piperidine / CHCl₃ / 2 h

3: 93.6 percent / Et₃N / CHCl₃ / 5 h

4: 40 percent / K₂CO₃ / dimethylformamide / 14 h

5: 88.3 percent / K₂CO₃; PhSH / dimethylformamide / 12 h / 20 °C

6: 79 percent / BOP; Et₃N / CH₂Cl₂ / 48 h / 20 °C

With potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; 4-Aminomethylpiperidine; thiophenol; triethylamine; In dichloromethane; chloroform; N,N-dimethyl-formamide; 1: Acylation / 2: deacylation / 3: Acylation / 4: Cyclization / 5: Substitution / 6: Acylation;
DOI:10.1002/(SICI)1522-2675(20000412)83:4<722::AID-HLCA722>3.0.CO;2-Z