2-(4-cyclopropyl-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Base Information

Chemical Name:2-(4-cyclopropyl-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
CAS No.:1338718-13-0
Molecular Formula:C₁₅H₂₀BFO₂
Molecular Weight:262.132
Hs Code.:

Synonyms:2-(4-cyclopropyl-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Suppliers and Price of 2-(4-cyclopropyl-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 2 raw suppliers

Chemical Property of 2-(4-cyclopropyl-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of 2-(4-cyclopropyl-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

There total 3 articles about 2-(4-cyclopropyl-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.1%

: 1030383-32-4
4-cyclopropyl-2-fluoro-1-iodobenzene

: 73183-34-3
bis(pinacol)diborane

: 1338718-13-0
2-(4-cyclopropyl-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Guidance literature:: With potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In N,N-dimethyl-formamide; at 90 ℃; for 16h; Inert atmosphere; Sealed tube;

Reference yield: 65.1%

: 73183-34-3
bis(pinacol)diborane

: 1338718-13-0
2-(4-cyclopropyl-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Guidance literature:: With potassium acetate; In N,N-dimethyl-formamide;

Reference yield:

: 256935-94-1
trifluoromethanesulfonic acid 3-fluoro-4-nitrophenyl ester

: 1338718-13-0
2-(4-cyclopropyl-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dichloromethane; toluene; water / 2.5 h / 90 °C / Inert atmosphere

2.1: ammonium chloride; iron / ethanol; water; tetrahydrofuran / 17 h / Inert atmosphere; Reflux

3.1: potassium iodide; sodium nitrite; sulfuric acid / dichloromethane; water / 0.08 h / 0 °C

3.2: 3 h / 60 °C

4.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 16 h / 90 °C / Inert atmosphere; Sealed tube

With sulfuric acid; potassium acetate; iron; ammonium chloride; caesium carbonate; potassium iodide; sodium nitrite; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 1.1: Suzuki Coupling;