(1''S,2'S)-(1-{1'-[1''-hydroxymethyl-3''-(tritylcarbamoyl)propylcarbamoyl]-2'-phenylethyl}-2-oxo-1,2-dihydropyridin-3-yl)carbamic acid tert-butyl ester

Base Information

Chemical Name:(1''S,2'S)-(1-{1'-[1''-hydroxymethyl-3''-(tritylcarbamoyl)propylcarbamoyl]-2'-phenylethyl}-2-oxo-1,2-dihydropyridin-3-yl)carbamic acid tert-butyl ester
CAS No.:422322-95-0
Molecular Formula:C₄₃H₄₆N₄O₆
Molecular Weight:714.861
Hs Code.:

Synonyms:(1''S,2'S)-(1-{1'-[1''-hydroxymethyl-3''-(tritylcarbamoyl)propylcarbamoyl]-2'-phenylethyl}-2-oxo-1,2-dihydropyridin-3-yl)carbamic acid tert-butyl ester

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Chemical Property of (1''S,2'S)-(1-{1'-[1''-hydroxymethyl-3''-(tritylcarbamoyl)propylcarbamoyl]-2'-phenylethyl}-2-oxo-1,2-dihydropyridin-3-yl)carbamic acid tert-butyl ester

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Technology Process of (1''S,2'S)-(1-{1'-[1''-hydroxymethyl-3''-(tritylcarbamoyl)propylcarbamoyl]-2'-phenylethyl}-2-oxo-1,2-dihydropyridin-3-yl)carbamic acid tert-butyl ester

There total 12 articles about (1''S,2'S)-(1-{1'-[1''-hydroxymethyl-3''-(tritylcarbamoyl)propylcarbamoyl]-2'-phenylethyl}-2-oxo-1,2-dihydropyridin-3-yl)carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 343566-39-2
(1''S,2'S)-(1-{1'-[1''-(tert-butyldimethylsilanyloxymethyl)-3''-(tritylcarbamoyl)propylcarbamoyl]-2'-phenylethyl}-2-oxo-1,2-dihydropyridin-3-yl)carbamic acid tert-butyl ester

: 422322-95-0
(1''S,2'S)-(1-{1'-[1''-hydroxymethyl-3''-(tritylcarbamoyl)propylcarbamoyl]-2'-phenylethyl}-2-oxo-1,2-dihydropyridin-3-yl)carbamic acid tert-butyl ester

Guidance literature:: With triethylamine trihydrofluoride; In acetonitrile; at 23 ℃;
DOI:10.1021/jm010469k

Reference yield:

: 6332-56-5
2-hydroxy-3-nitropyridine

: 422322-95-0
(1''S,2'S)-(1-{1'-[1''-hydroxymethyl-3''-(tritylcarbamoyl)propylcarbamoyl]-2'-phenylethyl}-2-oxo-1,2-dihydropyridin-3-yl)carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: H₂ / 10percent Pd/C / ethanol / 16 h / 760.05 Torr

2.1: 6.48 g / tetrahydrofuran / Heating

3.1: NaH / tetrahydrofuran / 0.33 h

3.2: 77 percent / NaH / tetrahydrofuran / 61 h / Heating

4.1: aq. triethylamine trihydrofluoride / acetonitrile / 23 °C

With triethylamine trihydrofluoride; hydrogen; sodium hydride; 10percent Pd/C; In tetrahydrofuran; ethanol; acetonitrile;
DOI:10.1021/jm010469k

Reference yield:

: 132388-60-4,200625-96-3
(S)-2-(((benzyloxy)carbonyl)amino)-5-oxo-5-(tritylamino)pentanoic acid

: 422322-95-0
(1''S,2'S)-(1-{1'-[1''-hydroxymethyl-3''-(tritylcarbamoyl)propylcarbamoyl]-2'-phenylethyl}-2-oxo-1,2-dihydropyridin-3-yl)carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: 4-methylmorpholine / tetrahydrofuran / 20 h / -10 °C

2.1: NaBH₄ / H₂O / 5 h / 23 °C

3.1: 7.6 g / imidazole / dimethylformamide

4.1: H₂ / Pd/C / ethanol / 23 °C / 2585.81 Torr

5.1: 4.85 g / i-Pr₂NEt; HATU / dimethylformamide / 1.42 h / 0 - 23 °C

6.1: i-Pr₂NEt / CH₂Cl₂

7.1: NaH / tetrahydrofuran / 0.33 h

7.2: 77 percent / NaH / tetrahydrofuran / 61 h / Heating

8.1: aq. triethylamine trihydrofluoride / acetonitrile / 23 °C

With 4-methyl-morpholine; 1H-imidazole; sodium tetrahydroborate; triethylamine trihydrofluoride; hydrogen; sodium hydride; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm010469k