C₁₂H₁₇ClFISi

Base Information

• Chemical Name: C₁₂H₁₇ClFISi
• CAS No.: 1260426-33-2
• Molecular Formula: C₁₂H₁₇ClFISi
• Molecular Weight: 370.708
• Mol file: 1260426-33-2.mol

Synonyms:C₁₂H₁₇ClFISi

Chemical Property of C₁₂H₁₇ClFISi

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₂H₁₇ClFISi

There total 5 articles about C₁₂H₁₇ClFISi which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

C17H21ClINSi (1260425-66-8) → C12H17ClFISi (1260426-33-2)

Guidance literature:

With hydrogen fluoride; In tetrahydrofuran; water; at 20 ℃; for 1h;

DOI:10.1002/anie.201004426

Reference yield:

2-(diisopropylsilyl)pyridine (1232692-92-0) → C12H17ClFISi (1260426-33-2)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium phosphate; di-μ-chlorobis(norbornadiene)dirhodium(I) / 1,4-dioxane / 20 °C / Inert atmosphere

2: N-iodo-succinimide; [bis(acetoxy)iodo]benzene; palladium diacetate / 1,2-dichloro-ethane / 1.2 h / 70 °C / Inert atmosphere

3: hydrogen fluoride / tetrahydrofuran; water / 1 h / 20 °C

With potassium phosphate; N-iodo-succinimide; di-μ-chlorobis(norbornadiene)dirhodium(I); [bis(acetoxy)iodo]benzene; hydrogen fluoride; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; water; 1,2-dichloro-ethane;

DOI:10.1002/adsc.201000975

Reference yield:

1-Chloro-4-iodobenzene (637-87-6) → C12H17ClFISi (1260426-33-2)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium phosphate; di-μ-chlorobis(norbornadiene)dirhodium(I) / 1,4-dioxane / 20 °C / Inert atmosphere

2: N-iodo-succinimide; [bis(acetoxy)iodo]benzene; palladium diacetate / 1,2-dichloro-ethane / 1.2 h / 70 °C / Inert atmosphere

3: hydrogen fluoride / tetrahydrofuran; water / 1 h / 20 °C

With potassium phosphate; N-iodo-succinimide; di-μ-chlorobis(norbornadiene)dirhodium(I); [bis(acetoxy)iodo]benzene; hydrogen fluoride; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; water; 1,2-dichloro-ethane;

DOI:10.1002/adsc.201000975

upstream raw materials:

C₁₇H₂₁ClINSi

2-(diisopropylsilyl)pyridine

2-((4-chlorophenyl)diisopropylsilyl)pyridine

1-Chloro-4-iodobenzene