N-{[1-(2-(piperazine-1-yl)ethyl)-pyrrolidine-(3R)-yl-carbamoyl]-methyl}-3-trifluoromethylbenzamide hydrochloride

Base Information

Chemical Name:N-{[1-(2-(piperazine-1-yl)ethyl)-pyrrolidine-(3R)-yl-carbamoyl]-methyl}-3-trifluoromethylbenzamide hydrochloride
CAS No.:1261061-74-8
Molecular Formula:C₂₀H₂₈F₃N₅O₂*ClH
Molecular Weight:463.931
Hs Code.:

Synonyms:N-{[1-(2-(piperazine-1-yl)ethyl)-pyrrolidine-(3R)-yl-carbamoyl]-methyl}-3-trifluoromethylbenzamide hydrochloride

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Chemical Property of N-{[1-(2-(piperazine-1-yl)ethyl)-pyrrolidine-(3R)-yl-carbamoyl]-methyl}-3-trifluoromethylbenzamide hydrochloride

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Technology Process of N-{[1-(2-(piperazine-1-yl)ethyl)-pyrrolidine-(3R)-yl-carbamoyl]-methyl}-3-trifluoromethylbenzamide hydrochloride

There total 6 articles about N-{[1-(2-(piperazine-1-yl)ethyl)-pyrrolidine-(3R)-yl-carbamoyl]-methyl}-3-trifluoromethylbenzamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1261061-73-7
N-{[1-(2-(4-tert-butoxycarbonylpiperazine-1-yl)ethyl)-pyrrolidine-(3R)-yl-carbamoyl]-methyl}-3-trifluoromethylbenzamide

: 1261061-74-8
N-{[1-(2-(piperazine-1-yl)ethyl)-pyrrolidine-(3R)-yl-carbamoyl]-methyl}-3-trifluoromethylbenzamide hydrochloride

Guidance literature:: With hydrogenchloride; In ethanol; at 20 ℃; for 1.5h;

Reference yield:

: N-[(1-benzylpyrrolidine-(3R)-yl-carbamoyl)-methyl]-3-trifluoromethylbenzamide

: 1261061-74-8
N-{[1-(2-(piperazine-1-yl)ethyl)-pyrrolidine-(3R)-yl-carbamoyl]-methyl}-3-trifluoromethylbenzamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: palladium(II) hydroxide / methanol / 20 °C / 760.05 Torr

2: potassium carbonate / acetonitrile / 24 h / 20 - 80 °C

3: hydrogenchloride / ethanol / 1.5 h / 20 °C

With hydrogenchloride; potassium carbonate; palladium(II) hydroxide; In methanol; ethanol; acetonitrile;

Reference yield:

: 17794-48-8
m-trifluoromethylhippuric acid

: 1261061-74-8
N-{[1-(2-(piperazine-1-yl)ethyl)-pyrrolidine-(3R)-yl-carbamoyl]-methyl}-3-trifluoromethylbenzamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / -10 °C / Inert atmosphere

1.2: 1 h / -10 °C / Inert atmosphere

2.1: hydrogen / palladium(II) hydroxide / methanol / 20 °C / 760.05 Torr

3.1: potassium carbonate / acetonitrile / 24 h / 80 °C

4.1: hydrogenchloride / ethanol / 1.5 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; hydrogen; potassium carbonate; isobutyl chloroformate; palladium(II) hydroxide; In tetrahydrofuran; methanol; ethanol; acetonitrile;