N-{[1-(2-(1-(methoxycarbonyl)-piperazine-4-yl)ethyl)-pyrrol idine-(3R)-yl-carbamoyl]-methyl}-3-trifluoromethylbenzamide

Base Information

Chemical Name:N-{[1-(2-(1-(methoxycarbonyl)-piperazine-4-yl)ethyl)-pyrrol idine-(3R)-yl-carbamoyl]-methyl}-3-trifluoromethylbenzamide
CAS No.:1261061-48-6
Molecular Formula:C₂₂H₃₀F₃N₅O₄
Molecular Weight:485.507
Hs Code.:

Synonyms:N-{[1-(2-(1-(methoxycarbonyl)-piperazine-4-yl)ethyl)-pyrrol idine-(3R)-yl-carbamoyl]-methyl}-3-trifluoromethylbenzamide

Suppliers and Price of N-{[1-(2-(1-(methoxycarbonyl)-piperazine-4-yl)ethyl)-pyrrol idine-(3R)-yl-carbamoyl]-methyl}-3-trifluoromethylbenzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-{[1-(2-(1-(methoxycarbonyl)-piperazine-4-yl)ethyl)-pyrrol idine-(3R)-yl-carbamoyl]-methyl}-3-trifluoromethylbenzamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-{[1-(2-(1-(methoxycarbonyl)-piperazine-4-yl)ethyl)-pyrrol idine-(3R)-yl-carbamoyl]-methyl}-3-trifluoromethylbenzamide

There total 7 articles about N-{[1-(2-(1-(methoxycarbonyl)-piperazine-4-yl)ethyl)-pyrrol idine-(3R)-yl-carbamoyl]-methyl}-3-trifluoromethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1261061-74-8
N-{[1-(2-(piperazine-1-yl)ethyl)-pyrrolidine-(3R)-yl-carbamoyl]-methyl}-3-trifluoromethylbenzamide hydrochloride

: 79-22-1
methyl chloroformate

: 1261061-48-6
N-{[1-(2-(1-(methoxycarbonyl)-piperazine-4-yl)ethyl)-pyrrol idine-(3R)-yl-carbamoyl]-methyl}-3-trifluoromethylbenzamide

Guidance literature:: With potassium carbonate; In acetonitrile; at 20 ℃; for 1h; Reflux;

Reference yield:

: N-[(1-benzylpyrrolidine-(3R)-yl-carbamoyl)-methyl]-3-trifluoromethylbenzamide

: 1261061-48-6
N-{[1-(2-(1-(methoxycarbonyl)-piperazine-4-yl)ethyl)-pyrrol idine-(3R)-yl-carbamoyl]-methyl}-3-trifluoromethylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: palladium(II) hydroxide / methanol / 20 °C / 760.05 Torr

2: potassium carbonate / acetonitrile / 24 h / 20 - 80 °C

3: hydrogenchloride / ethanol / 1.5 h / 20 °C

4: potassium carbonate / acetonitrile / 1 h / 20 °C / Reflux

With hydrogenchloride; potassium carbonate; palladium(II) hydroxide; In methanol; ethanol; acetonitrile;

Reference yield:

: 17794-48-8
m-trifluoromethylhippuric acid

: 1261061-48-6
N-{[1-(2-(1-(methoxycarbonyl)-piperazine-4-yl)ethyl)-pyrrol idine-(3R)-yl-carbamoyl]-methyl}-3-trifluoromethylbenzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / -10 °C / Inert atmosphere

1.2: 1 h / -10 °C / Inert atmosphere

2.1: hydrogen / palladium(II) hydroxide / methanol / 20 °C / 760.05 Torr

3.1: potassium carbonate / acetonitrile / 24 h / 80 °C

4.1: hydrogenchloride / ethanol / 1.5 h / 20 °C

5.1: potassium carbonate / acetonitrile / 1 h / Reflux

With 4-methyl-morpholine; hydrogenchloride; hydrogen; potassium carbonate; isobutyl chloroformate; palladium(II) hydroxide; In tetrahydrofuran; methanol; ethanol; acetonitrile;