5'-[(E)-2-(4-Benzyloxy-3-methoxy-phenyl)-vinyl]-5-[(E)-2-(2-bromo-5-methoxy-phenyl)-vinyl]-2,2'-dimethoxy-biphenyl

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Chemical Name:5'-[(E)-2-(4-Benzyloxy-3-methoxy-phenyl)-vinyl]-5-[(E)-2-(2-bromo-5-methoxy-phenyl)-vinyl]-2,2'-dimethoxy-biphenyl
CAS No.:776298-25-0
Molecular Formula:C₃₉H₃₅BrO₅
Molecular Weight:663.608
Hs Code.:

Synonyms:5'-[(E)-2-(4-Benzyloxy-3-methoxy-phenyl)-vinyl]-5-[(E)-2-(2-bromo-5-methoxy-phenyl)-vinyl]-2,2'-dimethoxy-biphenyl

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Chemical Property of 5'-[(E)-2-(4-Benzyloxy-3-methoxy-phenyl)-vinyl]-5-[(E)-2-(2-bromo-5-methoxy-phenyl)-vinyl]-2,2'-dimethoxy-biphenyl

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Technology Process of 5'-[(E)-2-(4-Benzyloxy-3-methoxy-phenyl)-vinyl]-5-[(E)-2-(2-bromo-5-methoxy-phenyl)-vinyl]-2,2'-dimethoxy-biphenyl

There total 11 articles about 5'-[(E)-2-(4-Benzyloxy-3-methoxy-phenyl)-vinyl]-5-[(E)-2-(2-bromo-5-methoxy-phenyl)-vinyl]-2,2'-dimethoxy-biphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 776298-23-8
(4-benzyloxy-3-methoxy-benzyl)-phosphonic acid dimethyl ester

: 776298-24-9
5'-[(E)-2-(2-Bromo-5-methoxy-phenyl)-vinyl]-6,2'-dimethoxy-biphenyl-3-carbaldehyde

: 776298-25-0
5'-[(E)-2-(4-Benzyloxy-3-methoxy-phenyl)-vinyl]-5-[(E)-2-(2-bromo-5-methoxy-phenyl)-vinyl]-2,2'-dimethoxy-biphenyl

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 3h;
DOI:10.1016/j.tetlet.2004.07.068

Reference yield:

: 2426-87-1
3-methoxy-4-(phenylmethoxy)benzaldehyde

: 776298-25-0
5'-[(E)-2-(4-Benzyloxy-3-methoxy-phenyl)-vinyl]-5-[(E)-2-(2-bromo-5-methoxy-phenyl)-vinyl]-2,2'-dimethoxy-biphenyl

Guidance literature:: Multi-step reaction with 4 steps

1: LiAlH₄ / tetrahydrofuran / 1 h / 0 - 20 °C

2: CBr₄; PPh₃ / acetonitrile / 9 h / 20 °C

3: 3 h / 90 °C

4: 75 percent / NaH / tetrahydrofuran / 3 h / 0 - 20 °C

With lithium aluminium tetrahydride; carbon tetrabromide; sodium hydride; triphenylphosphine; In tetrahydrofuran; acetonitrile; 3: Arbuzov reaction;
DOI:10.1016/j.tetlet.2004.07.068

Reference yield:

: 52674-09-6
2,2'-dimethoxydiphenyl-5,5'-bicarbaldehyde

: 776298-25-0
5'-[(E)-2-(4-Benzyloxy-3-methoxy-phenyl)-vinyl]-5-[(E)-2-(2-bromo-5-methoxy-phenyl)-vinyl]-2,2'-dimethoxy-biphenyl

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / NaH / tetrahydrofuran / 0 - 20 °C

2: 75 percent / NaH / tetrahydrofuran / 3 h / 0 - 20 °C

With sodium hydride; In tetrahydrofuran;
DOI:10.1016/j.tetlet.2004.07.068