2,5-dimethoxy-2,3,4,5-tetrahydrofurfuryl cyanoethyl 5'-O-(dimethoxytrityl)-N-isobutyryl-2'-deoxy-3'-guanylate

Base Information

Chemical Name:2,5-dimethoxy-2,3,4,5-tetrahydrofurfuryl cyanoethyl 5'-O-(dimethoxytrityl)-N-isobutyryl-2'-deoxy-3'-guanylate
CAS No.:249632-08-4
Molecular Formula:C₄₅H₅₃N₆O₁₃P
Molecular Weight:916.922
Hs Code.:

Synonyms:2,5-dimethoxy-2,3,4,5-tetrahydrofurfuryl cyanoethyl 5'-O-(dimethoxytrityl)-N-isobutyryl-2'-deoxy-3'-guanylate

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Chemical Property of 2,5-dimethoxy-2,3,4,5-tetrahydrofurfuryl cyanoethyl 5'-O-(dimethoxytrityl)-N-isobutyryl-2'-deoxy-3'-guanylate

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Technology Process of 2,5-dimethoxy-2,3,4,5-tetrahydrofurfuryl cyanoethyl 5'-O-(dimethoxytrityl)-N-isobutyryl-2'-deoxy-3'-guanylate

There total 3 articles about 2,5-dimethoxy-2,3,4,5-tetrahydrofurfuryl cyanoethyl 5'-O-(dimethoxytrityl)-N-isobutyryl-2'-deoxy-3'-guanylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Phosphorous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester 2,5-dimethoxy-tetrahydro-furan-2-ylmethyl ester

: 249632-08-4
2,5-dimethoxy-2,3,4,5-tetrahydrofurfuryl cyanoethyl 5'-O-(dimethoxytrityl)-N-isobutyryl-2'-deoxy-3'-guanylate

Guidance literature:: With pyridine; water; iodine; In tetrahydrofuran; at 20 ℃; for 0.333333h;
DOI:10.1021/ja991574a

Reference yield:

: 19969-71-2
2,5-dimethoxy-2-hydroxymethyl-2,5-dihydrofuran

: 249632-08-4
2,5-dimethoxy-2,3,4,5-tetrahydrofurfuryl cyanoethyl 5'-O-(dimethoxytrityl)-N-isobutyryl-2'-deoxy-3'-guanylate

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / H₂ / 10 percent Pd/C / methanol / 2 h / 20 °C

2: tetrazole; 4A-molecular sieves / acetonitrile / 1.5 h / 0 - 20 °C

3: I₂; H₂O; pyridine / tetrahydrofuran / 0.33 h / 20 °C

With pyridine; 1H-tetrazole; 4 A molecular sieve; water; hydrogen; iodine; palladium on activated charcoal; In tetrahydrofuran; methanol; acetonitrile; 1: Catalytic hydrogenation / 2: Condensation / 3: Oxidation;
DOI:10.1021/ja991574a

Reference yield:

: 66302-69-0
2,5-dimethoxy-2,3,4,5-tetrahydrofurfuryl alcohol

: 249632-08-4
2,5-dimethoxy-2,3,4,5-tetrahydrofurfuryl cyanoethyl 5'-O-(dimethoxytrityl)-N-isobutyryl-2'-deoxy-3'-guanylate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrazole; 4A-molecular sieves / acetonitrile / 1.5 h / 0 - 20 °C

2: I₂; H₂O; pyridine / tetrahydrofuran / 0.33 h / 20 °C

With pyridine; 1H-tetrazole; 4 A molecular sieve; water; iodine; In tetrahydrofuran; acetonitrile; 1: Condensation / 2: Oxidation;
DOI:10.1021/ja991574a