19969-71-2Relevant articles and documents
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Tanaka et al.
, p. 3482 (1976)
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Electroorganic synthesis of 2,5-dialkoxydihydrofurans and pyridazines on solid phase using polymer beads as supports
Nad, Sukanya,Breinbauer, Rolf
, p. 3654 - 3665 (2005)
Electroorganic synthesis has defied application in Solid-Phase Organic Synthesis (SPOS) so far. Typically more than 99.9% of the substrate molecules immobilized on a polymeric support are buried in the interior of the bead, and therefore are unable to undergo direct contact with a heterogeneous reagent such as an electrode. This intrinsic impediment for an electrochemical reaction can be overcome by the use of a redox mediator which shuttles electrons from the electrode to the polymer bound substrate molecules. This approach of indirect electroorganic synthesis was successfully applied for the 2,5-dialkoxylation of furans on solid phase. The oxidation products can be hydrolyzed and through condensation with hydrazine hydrate substituted pyridazines are produced in 50-65% overall yield. Georg Thieme Verlag Stuttgart.
The first de novo-designed antagonists of the human NK2 receptor
Ali, Mohammed A.,Bhogal, Nirmala,Findlay, John B. C.,Fishwick, Colin W. G.
, p. 5655 - 5658 (2005)
The de novo molecular design program SPROUT has been used in conjunction with a molecular model to produce a molecular template for a new class of NK2 receptor antagonist. An efficient, stereocontrolled synthesis of a small series of molecules,
