tert-butyl 5-(5-(3-cyano-4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl)-1H-indole-1-carboxylate

Base Information

Chemical Name:tert-butyl 5-(5-(3-cyano-4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl)-1H-indole-1-carboxylate
CAS No.:1307231-08-8
Molecular Formula:C₂₅H₂₄N₄O₄
Molecular Weight:444.49
Hs Code.:

Synonyms:tert-butyl 5-(5-(3-cyano-4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl)-1H-indole-1-carboxylate

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Chemical Property of tert-butyl 5-(5-(3-cyano-4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl)-1H-indole-1-carboxylate

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Technology Process of tert-butyl 5-(5-(3-cyano-4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl)-1H-indole-1-carboxylate

There total 4 articles about tert-butyl 5-(5-(3-cyano-4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl)-1H-indole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 258273-31-3
3-cyano-4-isopropoxybenzoic acid

: 1233500-95-2
tert-butyl 5-(N-hydroxycarbamimidoyl)-1H-indole-1-carboxylate

: 1307231-08-8
tert-butyl 5-(5-(3-cyano-4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl)-1H-indole-1-carboxylate

Guidance literature:: 3-cyano-4-isopropoxybenzoic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; at 20 ℃; for 1.5h; Inert atmosphere;

tert-butyl 5-(N-hydroxycarbamimidoyl)-1H-indole-1-carboxylate; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 475102-10-4
1-(tert-butoxycarbonyl)-1H-indole-5-carbonitrile

: 1307231-08-8
tert-butyl 5-(5-(3-cyano-4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl)-1H-indole-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydroxylamine hydrochloride; sodium carbonate / ethanol / 75 °C

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / 1.5 h / 20 °C / Inert atmosphere

2.2: 1 h / 20 °C

With hydroxylamine hydrochloride; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1307231-08-8
tert-butyl 5-(5-(3-cyano-4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl)-1H-indole-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap / acetonitrile / 0.5 h / 20 °C

2.1: hydroxylamine hydrochloride; sodium carbonate / ethanol / 75 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / 1.5 h / 20 °C / Inert atmosphere

3.2: 1 h / 20 °C

With dmap; hydroxylamine hydrochloride; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; acetonitrile;