475102-10-4

Basic information

• Product Name: 1-BOC-5-CYANOINDOLE
• Synonyms: 1-BOC-5-CYANOINDOLE;tert-Butyl 5-cyano-1H-indole-1-carboxylate;N-Boc-5-cyanoindole;N-(tert-Butoxycarbonyl)-5-cyanoindole
• CAS NO: 475102-10-4
• Molecular Formula: C₁₄H₁₄N₂O₂
• Molecular Weight: 242.27
• Product Categories: blocks;Carboxes;IndolesOxindoles;Indole
• Mol File: 475102-10-4.mol
• Article Data: 16

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-BOC-5-CYANOINDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BOC-5-CYANOINDOLE(475102-10-4)
• EPA Substance Registry System: 1-BOC-5-CYANOINDOLE(475102-10-4)

Safety Data

• Hazardous Substances Data: 475102-10-4(Hazardous Substances Data)

Usage

General Description

1-BOC-5-CYANOINDOLE is a synthetic intermediate chemical often used in research and development processes, especially in the pharmaceutical sector. It is known for its role in the synthesis and development of various pharmaceutical drugs and compounds. Despite being relatively stable under normal conditions, it should be handled and stored properly to avoid hazards. The exact properties of this chemical such as boiling point, melting point, molecular weight, density, refractive index, and flash point can vary and are subjected to specific test conditions. The chemical should only be used by trained professionals due to its potential risks and the need for specific handling and storage requirements.

Upstream product

• 15861-24-2 1H-indole-5-carbonitrile 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1259448-44-6 C₁₂H₁₄F₃NO₃SSi 
• 1259448-45-7 C₁₇H₂₂F₃NO₅SSi 
• 1259448-37-7 4-(trimethylsilyl)-1H-indol-5-yl trifluoromethanesulfonate 
• 1259448-38-8 C₁₇H₂₂F₃NO₅SSi 
• 557-21-1 zinc(II) cyanide 
• 182344-70-3 5-bromo-indole-1-carboxylic acid tert-butyl ester 

Downstream Products

• 15861-24-2 1H-indole-5-carbonitrile 
• 1186403-15-5 C₂₁H₁₇N₃O₂ 
• 871329-64-5 5-cyanoindole-2-boronic acid 
• 475102-15-9 (1-(tert-butoxycarbonyl)-5-cyano-1H-indol-2-yl)boronic acid 
• 1307230-51-8 5-(3-(1H-indol-5-yl)-1,2,4-oxadiazol-5-yl)-2-isopropoxybenzonitrile 
• 1307231-08-8 tert-butyl 5-(5-(3-cyano-4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl)-1H-indole-1-carboxylate 
• 279256-09-6 1-(tert-butyloxycarbonyl)indole-5-carboxaldehyde 

Relevant articles and documents

Discovery of Novel Indole-Based Allosteric Highly Potent ATX Inhibitors with Great in Vivo Efficacy in a Mouse Lung Fibrosis Model

Autotaxin (ATX) is the dominant catalytic enzyme accounting for the lipid mediator lysophosphatidic acid (LPA) through hydrolysis of lysophosphatidylcholine (LPC). There is great interest in developing nonacidic ATX inhibitors with a specific binding mode to serve as potential in vivo effective therapeutic tools. Herein, dating from a high-throughput screening (HTS) product Indole-1 (740 nM), a dedicated optimization campaign was implemented through derivatizing the-COOH group to versatile linkers that well-bridged the indole skeleton and the hydrophobic pocket binding groups. Ultimately, it was established that the coexistence of a carbamate linker and-OH-group-containing amines could generally furnish excellent indole-based ATX inhibitors with even below 1 nM in vitro activities. Two optimal entities were advanced to a bleomycin-induced mice pulmonary fibrosis model, which exerted promising efficacy in alleviating the damaged lung texture caused by bleomycin exposure. The novel carbamate-containing indole-based ATX inhibitors with a concrete binding mode may contribute to the identification of potential therapeutic agents to intervene in fibrotic diseases.

NOVEL OXADIAZOLE COMPOUNDS CONTAINING FUSED HETEROCYCLYL RINGS FOR CONTROLLING OR PREVENTING PHYTOPATHOGENIC FUNGI

The present invention discloses a compound of formula (I), wherein, R1, R2, R3, R4, A1 and Q are as defined in the detailed description and a process for preparing the compound of formula (I). The present invention also discloses a method for controlling or preventing phytopathogenic fungi.

Exploration of DAPI analogues: Synthesis, antitrypanosomal activity, DNA binding and fluorescence properties

The DAPI structure has been modified by replacing the phenyl group with substituted phenyl or heteroaryl rings. Twelve amidines were synthesized and their DNA binding, fluorescence properties, in?vitro and in?vivo activities were evaluated. These compounds are shown to bind in the DNA minor groove with high affinity, and exhibit superior in?vitro antitrypanosomal activity to that of DAPI. Six new diamidines (5b, 5c, 5d, 5e, 5f and 5j) exhibit superior in?vivo activity to that of DAPI and four of these compounds provide 100% animal cure at a low dose of 4?×?5?mg/kg i.p. in T.?b. rhodesiense infected mice. Generally, the fluorescence properties of the new analogues are inferior to that of DAPI with the exception of compound 5i which shows a moderate increase in efficacy while compound 5k is comparable to DAPI.