(3R)-3-{[4-(benzyloxy)phenyl]methyl}-4-[(4-methoxybenzene)sulfonyl]-7-(2-methoxypyridin-4-yl)-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine

Base Information

Chemical Name:(3R)-3-{[4-(benzyloxy)phenyl]methyl}-4-[(4-methoxybenzene)sulfonyl]-7-(2-methoxypyridin-4-yl)-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine
CAS No.:1402149-90-9
Molecular Formula:C₄₁H₄₁N₅O₅S
Molecular Weight:715.873
Hs Code.:

(3R)-3-{[4-(benzyloxy)phenyl]methyl}-4-[(4-methoxybenzene)sulfonyl]-7-(2-methoxypyridin-4-yl)-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine

Synonyms:(3R)-3-{[4-(benzyloxy)phenyl]methyl}-4-[(4-methoxybenzene)sulfonyl]-7-(2-methoxypyridin-4-yl)-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine

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Chemical Property of (3R)-3-{[4-(benzyloxy)phenyl]methyl}-4-[(4-methoxybenzene)sulfonyl]-7-(2-methoxypyridin-4-yl)-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine

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Technology Process of (3R)-3-{[4-(benzyloxy)phenyl]methyl}-4-[(4-methoxybenzene)sulfonyl]-7-(2-methoxypyridin-4-yl)-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine

There total 7 articles about (3R)-3-{[4-(benzyloxy)phenyl]methyl}-4-[(4-methoxybenzene)sulfonyl]-7-(2-methoxypyridin-4-yl)-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1402149-74-9
4-[(3R)-4-[(4-methoxybenzene)sulfonyl]-7-(2-methoxypyridin-4-yl)-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-zl]methyl phenol

: 100-39-0
benzyl bromide

: 1402149-90-9
(3R)-3-{[4-(benzyloxy)phenyl]methyl}-4-[(4-methoxybenzene)sulfonyl]-7-(2-methoxypyridin-4-yl)-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;
DOI:10.1021/jm300624s

Reference yield:

: 4692-98-2
5-bromoisatoic anhydride

: 1402149-90-9
(3R)-3-{[4-(benzyloxy)phenyl]methyl}-4-[(4-methoxybenzene)sulfonyl]-7-(2-methoxypyridin-4-yl)-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine; dmap / Reflux; Inert atmosphere

2.1: borane-THF / tetrahydrofuran / 18 h / Reflux; Inert atmosphere

3.1: pyridine / 16 h / 0 - 20 °C / Inert atmosphere

4.1: trifluoroacetic acid; trifluoroacetic anhydride / toluene / 2 h / 20 °C / Inert atmosphere

4.2: 16 h / 20 °C / Inert atmosphere

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water / 80 °C / Inert atmosphere

6.1: sodium hydride / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With pyridine; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; borane-THF; sodium hydride; potassium carbonate; trifluoroacetic acid; trifluoroacetic anhydride; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene; 5.1: |Suzuki Coupling;
DOI:10.1021/jm300624s

Reference yield:

: 1311269-26-7
(3R)-7-bromo-3-[(4-hydroxyphenyl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-2,5-dione

: 1402149-90-9
(3R)-3-{[4-(benzyloxy)phenyl]methyl}-4-[(4-methoxybenzene)sulfonyl]-7-(2-methoxypyridin-4-yl)-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine

Guidance literature:: Multi-step reaction with 5 steps

1.1: borane-THF / tetrahydrofuran / 18 h / Reflux; Inert atmosphere

2.1: pyridine / 16 h / 0 - 20 °C / Inert atmosphere

3.1: trifluoroacetic acid; trifluoroacetic anhydride / toluene / 2 h / 20 °C / Inert atmosphere

3.2: 16 h / 20 °C / Inert atmosphere

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water / 80 °C / Inert atmosphere

5.1: sodium hydride / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; borane-THF; sodium hydride; potassium carbonate; trifluoroacetic acid; trifluoroacetic anhydride; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene; 4.1: |Suzuki Coupling;
DOI:10.1021/jm300624s