Technology Process of C25H30ClN7O4S
There total 7 articles about C25H30ClN7O4S which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1,3-oxazolidine; (S)-N-(4-chloro-2-(2-(5,7-dichloropyrazolo[1,5-a]pyrimidin-2-yl)piperidine-1-carbonyl)phenyl)methanesulfonamide;
With
N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran;
at 70 ℃;
for 2h;
azetidine;
In
tetrahydrofuran;
at 70 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium bis(trimethylsilyl)amide / tetrahydrofuran / 0.42 h / -78 - -20 °C / Inert atmosphere
1.2: 3.08 h / -78 - -45 °C
1.3: -78 - 20 °C
2.1: hydrazinium monoacetate / ethanol / 16 h / 20 °C
3.1: sodium methylate / methanol / 5 h / 78 °C
4.1: trichlorophosphate / 3 h / 100 °C
5.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 3 h / 20 °C
5.2: 0.67 h / 20 °C / Cooling with ice
6.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 70 °C
6.2: 2 h / 70 °C
With
oxalyl dichloride; sodium bis(trimethylsilyl)amide; sodium methylate; hydrazinium monoacetate; N-ethyl-N,N-diisopropylamine; trichlorophosphate;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium bis(trimethylsilyl)amide / tetrahydrofuran; hexanes / -78 - -40 °C
1.2: -78 - -40 °C
1.3: -78 - 20 °C
2.1: hydrazinium monoacetate / ethanol / 16 h / 20 °C
3.1: sodium methylate / methanol / 5 h / 78 °C
4.1: trichlorophosphate / 3 h / 100 °C
5.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 3 h / 20 °C
5.2: 0.67 h / 20 °C / Cooling with ice
6.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 70 °C
6.2: 2 h / 70 °C
With
oxalyl dichloride; sodium bis(trimethylsilyl)amide; sodium methylate; hydrazinium monoacetate; N-ethyl-N,N-diisopropylamine; trichlorophosphate;
In
tetrahydrofuran; methanol; hexanes; ethanol; dichloromethane; N,N-dimethyl-formamide;