N-((2,2-dimethyl-2H-chromen-6-yl)methyl)-4-(4-(1,3-dioxoisoindolin-2-yl)butoxy)-3-methoxy-N-phenylbenzenesulfonamide

Base Information

• Chemical Name: N-((2,2-dimethyl-2H-chromen-6-yl)methyl)-4-(4-(1,3-dioxoisoindolin-2-yl)butoxy)-3-methoxy-N-phenylbenzenesulfonamide
• CAS No.: 1384840-68-9
• Molecular Formula: C₃₇H₃₆N₂O₇S
• Molecular Weight: 652.768

Synonyms:N-((2,2-dimethyl-2H-chromen-6-yl)methyl)-4-(4-(1,3-dioxoisoindolin-2-yl)butoxy)-3-methoxy-N-phenylbenzenesulfonamide

Chemical Property of N-((2,2-dimethyl-2H-chromen-6-yl)methyl)-4-(4-(1,3-dioxoisoindolin-2-yl)butoxy)-3-methoxy-N-phenylbenzenesulfonamide

Chemical Property:

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Technology Process of N-((2,2-dimethyl-2H-chromen-6-yl)methyl)-4-(4-(1,3-dioxoisoindolin-2-yl)butoxy)-3-methoxy-N-phenylbenzenesulfonamide

There total 2 articles about N-((2,2-dimethyl-2H-chromen-6-yl)methyl)-4-(4-(1,3-dioxoisoindolin-2-yl)butoxy)-3-methoxy-N-phenylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

N-((2,2-dimethyl-2H-chromen-6-yl)methyl)-4-hydroxy-3-methoxy-N-phenylbenzenesulfonamide + 2-(4-bromobutyl)isoindoline-1,3-dione (5394-18-3) → N-((2,2-dimethyl-2H-chromen-6-yl)methyl)-4-(4-(1,3-dioxoisoindolin-2-yl)butoxy)-3-methoxy-N-phenylbenzenesulfonamide (1384840-68-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 4h; Inert atmosphere;

DOI:10.1021/ml300042k

Reference yield:

3,4-dimethoxy-N-[(2,2-dimethyl-2H-chromen-6-yl)methyl]-N-phenylbenzenesulfonamide (927823-01-6) → N-((2,2-dimethyl-2H-chromen-6-yl)methyl)-4-(4-(1,3-dioxoisoindolin-2-yl)butoxy)-3-methoxy-N-phenylbenzenesulfonamide (1384840-68-9)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate; thiophenol / 1-methyl-pyrrolidin-2-one / 0.5 h / 100 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 4 h / 60 °C / Inert atmosphere

With potassium carbonate; thiophenol; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;

DOI:10.1021/ml300042k

Reference yield: 76.0%

N-((2,2-dimethyl-2H-chromen-6-yl)methyl)-4-(4-(1,3-dioxoisoindolin-2-yl)butoxy)-3-methoxy-N-phenylbenzenesulfonamide (1384840-68-9) → 4-(4-aminobutoxy)-N-((2,2-dimethyl-2H-chromen-6-yl)methyl)-3-methoxy-N-phenylbenzenesulfonamide (1384840-69-0)

Guidance literature:

With hydrazine hydrate; In ethanol; dichloromethane; for 3h; Inert atmosphere; Reflux;

DOI:10.1021/ml300042k

upstream raw materials:

3,4-dimethoxy-N-[(2,2-dimethyl-2H-chromen-6-yl)methyl]-N-phenylbenzenesulfonamide

2-(4-bromobutyl)isoindoline-1,3-dione

Downstream raw materials:

4-(4-aminobutoxy)-N-((2,2-dimethyl-2H-chromen-6-yl)methyl)-3-methoxy-N-phenylbenzenesulfonamide

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