N-(5-(3-(2H-tetrazol-5-yl)imidazo[1,2-a]pyridin-6-yl)pyridin-3-yl)-benzenesulfonamide

Base Information

Chemical Name:N-(5-(3-(2H-tetrazol-5-yl)imidazo[1,2-a]pyridin-6-yl)pyridin-3-yl)-benzenesulfonamide
CAS No.:1276110-12-3
Molecular Formula:C₁₉H₁₄N₈O₂S
Molecular Weight:418.439
Hs Code.:

Synonyms:N-(5-(3-(2H-tetrazol-5-yl)imidazo[1,2-a]pyridin-6-yl)pyridin-3-yl)-benzenesulfonamide

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Chemical Property of N-(5-(3-(2H-tetrazol-5-yl)imidazo[1,2-a]pyridin-6-yl)pyridin-3-yl)-benzenesulfonamide

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Technology Process of N-(5-(3-(2H-tetrazol-5-yl)imidazo[1,2-a]pyridin-6-yl)pyridin-3-yl)-benzenesulfonamide

There total 7 articles about N-(5-(3-(2H-tetrazol-5-yl)imidazo[1,2-a]pyridin-6-yl)pyridin-3-yl)-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1276110-04-3
N-(5-(3-cyanoimidazo[1,2-a]pyridin-6-yl)pyridin-3-yl)benzenesulfonamide

: 1276110-12-3
N-(5-(3-(2H-tetrazol-5-yl)imidazo[1,2-a]pyridin-6-yl)pyridin-3-yl)-benzenesulfonamide

Guidance literature:: With sodium azide; cadmium(II) chloride; In N,N-dimethyl-formamide; at 80 ℃; for 12h; Inert atmosphere;
DOI:10.1021/jm101582z

Reference yield:

: 13535-01-8
3-amino-5-bromopyridine

: 1276110-12-3
N-(5-(3-(2H-tetrazol-5-yl)imidazo[1,2-a]pyridin-6-yl)pyridin-3-yl)-benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / dichloromethane / 20 °C / Inert atmosphere

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / dichloromethane / 100 °C / Inert atmosphere

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / 1,4-dioxane; water / 12 h / 100 °C / Inert atmosphere

4: sodium azide; cadmium(II) chloride / N,N-dimethyl-formamide / 12 h / 80 °C / Inert atmosphere

With pyridine; sodium azide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; potassium carbonate; cadmium(II) chloride; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; 3: Suzuki coupling;
DOI:10.1021/jm101582z

Reference yield:

: 1072-97-5
5-bromo-2-pyridylamine

: 1276110-12-3
N-(5-(3-(2H-tetrazol-5-yl)imidazo[1,2-a]pyridin-6-yl)pyridin-3-yl)-benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: methanol / 6 h / 70 °C / Inert atmosphere

2: sodium hydrogencarbonate / isopropyl alcohol / 12 h / 100 °C / Inert atmosphere

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / 1,4-dioxane; water / 12 h / 100 °C / Inert atmosphere

4: sodium azide; cadmium(II) chloride / N,N-dimethyl-formamide / 12 h / 80 °C / Inert atmosphere

With sodium azide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydrogencarbonate; potassium carbonate; cadmium(II) chloride; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; isopropyl alcohol; 3: Suzuki coupling;
DOI:10.1021/jm101582z