Carbamic acid, (2-oxo-3-cyclopenten-1-yl)-, 1,1-dimethylethyl ester, (S)- (9CI)

Base Information

Chemical Name:Carbamic acid, (2-oxo-3-cyclopenten-1-yl)-, 1,1-dimethylethyl ester, (S)- (9CI)
CAS No.:183606-89-5
Molecular Formula:C₁₀H₁₅NO₃
Molecular Weight:197.234
Hs Code.:
Mol file:183606-89-5.mol

Synonyms:Carbamicacid, (2-oxo-3-cyclopenten-1-yl)-, 1,1-dimethylethyl ester, (S)-; Carbamic acid,[(1S)-2-oxo-3-cyclopenten-1-yl]-, 1,1-dimethylethyl ester (9CI)

Suppliers and Price of Carbamic acid, (2-oxo-3-cyclopenten-1-yl)-, 1,1-dimethylethyl ester, (S)- (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Carbamic acid, (2-oxo-3-cyclopenten-1-yl)-, 1,1-dimethylethyl ester, (S)- (9CI)

Chemical Property:

PSA：55.40000
LogP:1.79960

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of Carbamic acid, (2-oxo-3-cyclopenten-1-yl)-, 1,1-dimethylethyl ester, (S)- (9CI)

There total 8 articles about Carbamic acid, (2-oxo-3-cyclopenten-1-yl)-, 1,1-dimethylethyl ester, (S)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: ((S)-2-Bromo-1,1,5-trioxo-hexahydro-1λ⁶-thiopyran-4-yl)-carbamic acid tert-butyl ester

: 183606-89-5
((S)-2-Oxo-cyclopent-3-enyl)-carbamic acid tert-butyl ester

Guidance literature:: With sodium acetate; In tetrahydrofuran; methanol; water; for 10h; Heating;
DOI:10.1016/0040-4039(96)01610-3

Reference yield: 48.0%

: ((S)-2-Chloro-1,1,5-trioxo-hexahydro-1λ⁶-thiopyran-4-yl)-carbamic acid tert-butyl ester

: 183606-89-5
((S)-2-Oxo-cyclopent-3-enyl)-carbamic acid tert-butyl ester

Guidance literature:: With sodium acetate; In tetrahydrofuran; methanol; water; for 10h; Heating;
DOI:10.1016/0040-4039(96)01610-3

Reference yield:

: 33900-24-2
N-(tert-butoxycarbonyl)-L-methionine methyl ester

: 183606-89-5
((S)-2-Oxo-cyclopent-3-enyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 76 percent / oxine

2: 88 percent / KHMDS / tetrahydrofuran; toluene / -78 deg C --> 0 deg C, 2-3 h, then 0 deg C --> room temp., 30 min

3: NaBH₄ / methanol / 0.5 h / Ambient temperature

4: 71 percent / LDA, Cl₃CCCl₃ / tetrahydrofuran / -78 °C

5: 69 percent / PCC, AcONa, 4 Angstoem mol. sieves / CH₂Cl₂

6: 48 percent / AcONa / tetrahydrofuran; H₂O; methanol / 10 h / Heating

With sodium tetrahydroborate; 8-quinolinol; hexachloroethane; 4 A molecular sieve; sodium acetate; potassium hexamethylsilazane; pyridinium chlorochromate; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; water; toluene;
DOI:10.1016/0040-4039(96)01610-3