ethyl [4-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1H-1,2,3-triazol-1-yl][2-(trifluoromethyl)phenyl]acetate

Base Information

Chemical Name:ethyl [4-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1H-1,2,3-triazol-1-yl][2-(trifluoromethyl)phenyl]acetate
CAS No.:1332502-28-9
Molecular Formula:C₂₅H₂₁ClF₆N₆O₄
Molecular Weight:618.923
Hs Code.:

ethyl [4-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1H-1,2,3-triazol-1-yl][2-(trifluoromethyl)phenyl]acetate

Synonyms:ethyl [4-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1H-1,2,3-triazol-1-yl][2-(trifluoromethyl)phenyl]acetate

Suppliers and Price of ethyl [4-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1H-1,2,3-triazol-1-yl][2-(trifluoromethyl)phenyl]acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl [4-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1H-1,2,3-triazol-1-yl][2-(trifluoromethyl)phenyl]acetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl [4-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1H-1,2,3-triazol-1-yl][2-(trifluoromethyl)phenyl]acetate

There total 7 articles about ethyl [4-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1H-1,2,3-triazol-1-yl][2-(trifluoromethyl)phenyl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

: 1332502-74-5
5-(4-chlorophenyl)-2-(prop-2-yn-1-yl)-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

: ethyl α-bromo-(2-trifluoromethylphenyl)acetate

: 1332502-28-9
ethyl [4-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1H-1,2,3-triazol-1-yl][2-(trifluoromethyl)phenyl]acetate

Guidance literature:: ethyl α-bromo-(2-trifluoromethylphenyl)acetate; With sodium azide; In acetonitrile; at 20 ℃; for 1h;

5-(4-chlorophenyl)-2-(prop-2-yn-1-yl)-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one; With copper(II) acetate monohydrate; In acetonitrile; at 50 ℃; for 20h;

Reference yield:

: 81580-50-9
ethyl 2-(2-(trifluoromethyl)phenyl)acetate

: 1332502-28-9
ethyl [4-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1H-1,2,3-triazol-1-yl][2-(trifluoromethyl)phenyl]acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium bromate; sodium hydrogensulfite / water; ethyl acetate / 18 h / 20 °C

2.1: sodium azide / acetonitrile / 1 h / 20 °C

2.2: 20 h / 50 °C

With sodium bromate; sodium azide; sodium hydrogensulfite; In water; ethyl acetate; acetonitrile;

Reference yield:

: 536-40-3
4-chlorobenzoic acid hydrazide

: 1332502-28-9
ethyl [4-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1H-1,2,3-triazol-1-yl][2-(trifluoromethyl)phenyl]acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrahydrofuran / 50 °C

2.1: sodium hydroxide; water / Reflux

2.2: 20 °C / pH 1

3.1: pyridine / 0.5 h / 35 °C / Inert atmosphere

3.2: 70 °C

4.1: formic acid; triethylamine; [N-[(1R,2R)-2-(amino-κN)-1,2-diphenylethyl]-4-methylbenzenesulfonamidato-κN]chloro[(1,2, 3,4,5,6-η)-1-methyl-4-(1-methylethyl)benzene]-ruthenium / N,N-dimethyl acetamide / 48 h / 20 °C / Inert atmosphere

5.1: caesium carbonate / acetonitrile / 1 h / Reflux

6.1: sodium azide / acetonitrile / 1 h / 20 °C

6.2: 20 h / 50 °C

With pyridine; formic acid; sodium azide; [N-[(1R,2R)-2-(amino-κN)-1,2-diphenylethyl]-4-methylbenzenesulfonamidato-κN]chloro[(1,2, 3,4,5,6-η)-1-methyl-4-(1-methylethyl)benzene]-ruthenium; water; caesium carbonate; triethylamine; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl acetamide; acetonitrile;