tert-butyl(2-(chloromethyl)-5-methoxyphenoxy)dimethylsilane

Base Information

• Chemical Name: tert-butyl(2-(chloromethyl)-5-methoxyphenoxy)dimethylsilane
• CAS No.: 1446839-99-1
• Molecular Formula: C₁₄H₂₃BrO₂Si
• Molecular Weight: 331.325
• Mol file: 1446839-99-1.mol

Synonyms:tert-butyl(2-(chloromethyl)-5-methoxyphenoxy)dimethylsilane

Chemical Property of tert-butyl(2-(chloromethyl)-5-methoxyphenoxy)dimethylsilane

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of tert-butyl(2-(chloromethyl)-5-methoxyphenoxy)dimethylsilane

There total 1 articles about tert-butyl(2-(chloromethyl)-5-methoxyphenoxy)dimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(2-((tert-butyldimethylsilyl)oxy)-5-methoxyphenyl)methanol (736985-95-8) → tert-butyl(2-(chloromethyl)-5-methoxyphenoxy)dimethylsilane (1446839-99-1)

Guidance literature:

With phosphorus tribromide; In diethyl ether; at 0 ℃; for 1h; Inert atmosphere;

DOI:10.1021/ja405833m

Reference yield: 89.0%

2-acetylpropanoic acid ethyl ester (609-14-3) + tert-butyl(2-(chloromethyl)-5-methoxyphenoxy)dimethylsilane (1446839-99-1) + acetyl chloride (75-36-5) → C17H22O6

Guidance literature:

2-acetylpropanoic acid ethyl ester; tert-butyl(2-(chloromethyl)-5-methoxyphenoxy)dimethylsilane; With potassium fluoride; CHF₃O₃S*C₁₀H₂₄N₂; 3-nitrobenzoic acid; In acetonitrile; at 20 ℃; for 20h;

acetyl chloride; With triethylamine; In dichloromethane; at 0 - 20 ℃; for 6h; enantioselective reaction;

DOI:10.1002/chem.201605302

Reference yield: 80.0%

tert-butyl(2-(chloromethyl)-5-methoxyphenoxy)dimethylsilane (1446839-99-1) + 2-ethoxycarbonyl-1-cyclopentanone (611-10-9) + acetyl chloride (75-36-5) → C18H22O6

Guidance literature:

tert-butyl(2-(chloromethyl)-5-methoxyphenoxy)dimethylsilane; 2-ethoxycarbonyl-1-cyclopentanone; With potassium fluoride; CHF₃O₃S*C₁₀H₂₄N₂; 3-nitrobenzoic acid; In acetonitrile; at 20 ℃; for 20h;

acetyl chloride; With triethylamine; In dichloromethane; at 0 - 20 ℃; for 6h; enantioselective reaction;

DOI:10.1002/chem.201605302

upstream raw materials:

(2-((tert-butyldimethylsilyl)oxy)-5-methoxyphenyl)methanol

Downstream raw materials:

(R)-7-methoxy-4-phenyl-4,5-dihydrobenzo[b]oxepin-2(3H)-one