(R)-2-azido-1-(6,8-bis(benzyloxy)-1-(2-(2-nitrophenylselanyl)ethyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone

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Chemical Name:(R)-2-azido-1-(6,8-bis(benzyloxy)-1-(2-(2-nitrophenylselanyl)ethyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone
CAS No.:1384461-44-2
Molecular Formula:C₃₃H₃₁N₅O₅Se
Molecular Weight:656.6
Hs Code.:

Synonyms:(R)-2-azido-1-(6,8-bis(benzyloxy)-1-(2-(2-nitrophenylselanyl)ethyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone

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Chemical Property of (R)-2-azido-1-(6,8-bis(benzyloxy)-1-(2-(2-nitrophenylselanyl)ethyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone

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Technology Process of (R)-2-azido-1-(6,8-bis(benzyloxy)-1-(2-(2-nitrophenylselanyl)ethyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone

There total 6 articles about (R)-2-azido-1-(6,8-bis(benzyloxy)-1-(2-(2-nitrophenylselanyl)ethyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 51694-22-5
ortho-nitrophenyl selenocyanate

: 1384461-38-4
(R)-2-azido-1-(6,8-bis(benzyloxy)-1-(2-hydroxyethyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone

: 1384461-44-2
(R)-2-azido-1-(6,8-bis(benzyloxy)-1-(2-(2-nitrophenylselanyl)ethyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone

Guidance literature:: With tributylphosphine; In tetrahydrofuran; for 4h; Inert atmosphere;
DOI:10.1039/c2ob25772f

Reference yield:

: 1384461-36-2
C₂₆H₂₇NO₂

: 1384461-44-2
(R)-2-azido-1-(6,8-bis(benzyloxy)-1-(2-(2-nitrophenylselanyl)ethyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone

Guidance literature:: Multi-step reaction with 4 steps

1: dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 12 h / Inert atmosphere

2: sodium periodate / tetrahydrofuran; water / 0.33 h / Inert atmosphere

3: sodium tetrahydroborate / methanol / 0.08 h / Inert atmosphere

4: tributylphosphine / tetrahydrofuran / 4 h / Inert atmosphere

With dmap; sodium tetrahydroborate; sodium periodate; tributylphosphine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; water;
DOI:10.1039/c2ob25772f

Reference yield:

: 1384461-35-1
6,8-bis(benzyloxy)-3,4-dihydroisoquinoline

: 1384461-44-2
(R)-2-azido-1-(6,8-bis(benzyloxy)-1-(2-(2-nitrophenylselanyl)ethyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran / 5 h / -78 - 0 °C / Inert atmosphere

2: dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 12 h / Inert atmosphere

3: sodium periodate / tetrahydrofuran; water / 0.33 h / Inert atmosphere

4: sodium tetrahydroborate / methanol / 0.08 h / Inert atmosphere

5: tributylphosphine / tetrahydrofuran / 4 h / Inert atmosphere

With dmap; sodium tetrahydroborate; sodium periodate; tributylphosphine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; water;
DOI:10.1039/c2ob25772f