6,8-bis(benzyloxy)-3,4-dihydroisoquinoline

Base Information

Chemical Name:6,8-bis(benzyloxy)-3,4-dihydroisoquinoline
CAS No.:1384461-35-1
Molecular Formula:C₂₃H₂₁NO₂
Molecular Weight:343.425
Hs Code.:

Synonyms:6,8-bis(benzyloxy)-3,4-dihydroisoquinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6,8-bis(benzyloxy)-3,4-dihydroisoquinoline

Chemical Property:

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Technology Process of 6,8-bis(benzyloxy)-3,4-dihydroisoquinoline

There total 1 articles about 6,8-bis(benzyloxy)-3,4-dihydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 100-97-0
hexamethylenetetramine

: 188662-05-7
<2-<3,5-bis(benzyloxy)phenyl>ethyl>amine

: 1384461-35-1
6,8-bis(benzyloxy)-3,4-dihydroisoquinoline

Guidance literature:: With acetic acid; In trifluoroacetic acid; at 90 ℃; for 3h; Inert atmosphere;
DOI:10.1039/c2ob25772f

Reference yield:

: 1384461-35-1
6,8-bis(benzyloxy)-3,4-dihydroisoquinoline

: 949463-54-1
(3S,11bR)-3-amino-9,11-bis(benzyloxy)-2,3,6,7-tetrahydro-1H-pyrido[2,1-a]isoquinolin-4(11bH)-one

Guidance literature:: Multi-step reaction with 9 steps

1: tetrahydrofuran / 5 h / -78 - 0 °C / Inert atmosphere

2: dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 12 h / Inert atmosphere

3: sodium periodate / tetrahydrofuran; water / 0.33 h / Inert atmosphere

4: sodium tetrahydroborate / methanol / 0.08 h / Inert atmosphere

5: tributylphosphine / tetrahydrofuran / 4 h / Inert atmosphere

6: dihydrogen peroxide / tetrahydrofuran / 6 h / 45 °C / Inert atmosphere

7: triphenylphosphine / tetrahydrofuran; water / 12 h / Inert atmosphere

8: isopropylmagnesium chloride / tetrahydrofuran; benzene / 1 h / 50 °C / Inert atmosphere

9: toluene-4-sulfonic acid / benzene / 24 h / Inert atmosphere

With dmap; sodium tetrahydroborate; sodium periodate; tributylphosphine; dihydrogen peroxide; isopropylmagnesium chloride; benzotriazol-1-ol; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; In tetrahydrofuran; methanol; water; benzene; 8: Aza-Claisen rearrangement;
DOI:10.1039/c2ob25772f

Reference yield:

: 1384461-35-1
6,8-bis(benzyloxy)-3,4-dihydroisoquinoline

: schulzeine C

Guidance literature:: Multi-step reaction with 8 steps

1: tetrahydrofuran / 5 h / -78 - 0 °C / Inert atmosphere

2: dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 12 h / Inert atmosphere

3: sodium periodate / tetrahydrofuran; water / 0.33 h / Inert atmosphere

4: sodium tetrahydroborate / methanol / 0.08 h / Inert atmosphere

5: tributylphosphine / tetrahydrofuran / 4 h / Inert atmosphere

6: dihydrogen peroxide / tetrahydrofuran / 6 h / 45 °C / Inert atmosphere

7: triphenylphosphine / tetrahydrofuran; water / 12 h / Inert atmosphere

8: Inert atmosphere

With dmap; sodium tetrahydroborate; sodium periodate; tributylphosphine; dihydrogen peroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; In tetrahydrofuran; methanol; water; 8: Aza-Claisen rearrangement;
DOI:10.1039/c2ob25772f