(4E,8E)-(6R,7R)-9-(Dimethyl-phenyl-silanyl)-6-(3-methoxy-propyl)-7-methyl-nona-4,8-dienal

Base Information

Chemical Name:(4E,8E)-(6R,7R)-9-(Dimethyl-phenyl-silanyl)-6-(3-methoxy-propyl)-7-methyl-nona-4,8-dienal
CAS No.:96720-43-3
Molecular Formula:C₂₂H₃₄O₂Si
Molecular Weight:358.596
Hs Code.:

Synonyms:(4E,8E)-(6R,7R)-9-(Dimethyl-phenyl-silanyl)-6-(3-methoxy-propyl)-7-methyl-nona-4,8-dienal

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Chemical Property of (4E,8E)-(6R,7R)-9-(Dimethyl-phenyl-silanyl)-6-(3-methoxy-propyl)-7-methyl-nona-4,8-dienal

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Technology Process of (4E,8E)-(6R,7R)-9-(Dimethyl-phenyl-silanyl)-6-(3-methoxy-propyl)-7-methyl-nona-4,8-dienal

There total 7 articles about (4E,8E)-(6R,7R)-9-(Dimethyl-phenyl-silanyl)-6-(3-methoxy-propyl)-7-methyl-nona-4,8-dienal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 96720-42-2,96789-54-7
(E)-(4S,5R)-7-(Dimethyl-phenyl-silanyl)-4-(3-methoxy-propyl)-5-methyl-hepta-1,6-dien-3-ol

: 109-92-2,25104-37-4
ethyl vinyl ether

: 96720-43-3
(4E,8E)-(6R,7R)-9-(Dimethyl-phenyl-silanyl)-6-(3-methoxy-propyl)-7-methyl-nona-4,8-dienal

Guidance literature:: With mercury(II) trifluoroacetate; In benzene; at 200 ℃; for 2h;
DOI:10.1016/S0040-4039(00)98414-4

Reference yield:

: 3839-31-4
dimethyl(phenyl)silyllithium

: 96720-43-3
(4E,8E)-(6R,7R)-9-(Dimethyl-phenyl-silanyl)-6-(3-methoxy-propyl)-7-methyl-nona-4,8-dienal

Guidance literature:: Multi-step reaction with 7 steps

1: 55 percent / tetrahydrofuran / -100 °C

2: 87 percent / pyridine; benzene / 6 h / 0 - 25 °C

3: 1.) LDA, t-BuMe₂SiCl, TMEDA 2.) aq HCl / 1.) THF, -78 gradC to 25 gradC, 3 h 2.) 12 h

4: diethyl ether / 0 - 25 °C

5: 1.) LiAlH₄ 2.) CrO₃*2pyr / 1.) Et₂O, 0 gradC to 25 gradC 2.) CH₂Cl₂

6: 75 percent / tetrahydrofuran / 0.33 h / -78 °C

7: 81 percent / Hg(OCOCF₃)2 / benzene / 2 h / 200 °C

With hydrogenchloride; lithium aluminium tetrahydride; N,N,N,N,-tetramethylethylenediamine; mercury(II) trifluoroacetate; dipyridine chromium trioxide; tert-butyldimethylsilyl chloride; lithium diisopropyl amide; In tetrahydrofuran; pyridine; diethyl ether; benzene;
DOI:10.1016/S0040-4039(00)98414-4

Reference yield:

: 96720-38-6
(E)-1-(phenyldimethylsilyl)-2-buten-1-ol

: 96720-43-3
(4E,8E)-(6R,7R)-9-(Dimethyl-phenyl-silanyl)-6-(3-methoxy-propyl)-7-methyl-nona-4,8-dienal

Guidance literature:: Multi-step reaction with 6 steps

1: 87 percent / pyridine; benzene / 6 h / 0 - 25 °C

2: 1.) LDA, t-BuMe₂SiCl, TMEDA 2.) aq HCl / 1.) THF, -78 gradC to 25 gradC, 3 h 2.) 12 h

3: diethyl ether / 0 - 25 °C

4: 1.) LiAlH₄ 2.) CrO₃*2pyr / 1.) Et₂O, 0 gradC to 25 gradC 2.) CH₂Cl₂

5: 75 percent / tetrahydrofuran / 0.33 h / -78 °C

6: 81 percent / Hg(OCOCF₃)2 / benzene / 2 h / 200 °C

With hydrogenchloride; lithium aluminium tetrahydride; N,N,N,N,-tetramethylethylenediamine; mercury(II) trifluoroacetate; dipyridine chromium trioxide; tert-butyldimethylsilyl chloride; lithium diisopropyl amide; In tetrahydrofuran; pyridine; diethyl ether; benzene;
DOI:10.1016/S0040-4039(00)98414-4