{3-chloro-5-[1-(3-chloro-5-hydroxymethyl-4-methoxy-phenyl)-5-(2-ethyl-[1,3]dioxolan-2-yl)-pent-1-enyl]-2-methoxy-phenyl}-methanol

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Chemical Name:{3-chloro-5-[1-(3-chloro-5-hydroxymethyl-4-methoxy-phenyl)-5-(2-ethyl-[1,3]dioxolan-2-yl)-pent-1-enyl]-2-methoxy-phenyl}-methanol
CAS No.:252934-41-1
Molecular Formula:C₂₆H₃₂Cl₂O₆
Molecular Weight:511.442
Hs Code.:

Synonyms:{3-chloro-5-[1-(3-chloro-5-hydroxymethyl-4-methoxy-phenyl)-5-(2-ethyl-[1,3]dioxolan-2-yl)-pent-1-enyl]-2-methoxy-phenyl}-methanol

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Chemical Property of {3-chloro-5-[1-(3-chloro-5-hydroxymethyl-4-methoxy-phenyl)-5-(2-ethyl-[1,3]dioxolan-2-yl)-pent-1-enyl]-2-methoxy-phenyl}-methanol

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Technology Process of {3-chloro-5-[1-(3-chloro-5-hydroxymethyl-4-methoxy-phenyl)-5-(2-ethyl-[1,3]dioxolan-2-yl)-pent-1-enyl]-2-methoxy-phenyl}-methanol

There total 3 articles about {3-chloro-5-[1-(3-chloro-5-hydroxymethyl-4-methoxy-phenyl)-5-(2-ethyl-[1,3]dioxolan-2-yl)-pent-1-enyl]-2-methoxy-phenyl}-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.5%

: 252934-39-7
C₂₈H₃₂Cl₂O₈

: 3',3''-dichloro-4',4''-dimethoxy-5'-formyl-5''-hydroxymethyl-1,1-diphenyl-5-(2-ethyl-(1,3)-dioxolan-2-yl)-1-pentene

: 252934-41-1
{3-chloro-5-[1-(3-chloro-5-hydroxymethyl-4-methoxy-phenyl)-5-(2-ethyl-[1,3]dioxolan-2-yl)-pent-1-enyl]-2-methoxy-phenyl}-methanol

Guidance literature:: With diisobutylaluminium hydride; In dichloromethane; toluene; at -78 ℃; for 4h;
DOI:10.1021/jm990343b

Reference yield:

: 128685-73-4
4-(2-Ethyl-[1,3]dioxolan-2-yl)-butyraldehyde

: 252934-41-1
{3-chloro-5-[1-(3-chloro-5-hydroxymethyl-4-methoxy-phenyl)-5-(2-ethyl-[1,3]dioxolan-2-yl)-pent-1-enyl]-2-methoxy-phenyl}-methanol

Guidance literature:: Multi-step reaction with 2 steps

1: 75.5 percent / TiCl₄*2THF; Zn / tetrahydrofuran / 1.5 h / Heating

2: 93.5 percent / DIBAL-H / CH₂Cl₂; toluene / 4 h / -78 °C

With tetrachlorobis(tetrahydrofuran)titanium(IV); diisobutylaluminium hydride; zinc; In tetrahydrofuran; dichloromethane; toluene; 1: Condensation / 2: Reduction;
DOI:10.1021/jm990343b

Reference yield:

: 154023-65-1
3,3'-dichloro-4,4'-dimethoxy-5,5'-bis(methoxycarbonyl)benzophenone

: 252934-41-1
{3-chloro-5-[1-(3-chloro-5-hydroxymethyl-4-methoxy-phenyl)-5-(2-ethyl-[1,3]dioxolan-2-yl)-pent-1-enyl]-2-methoxy-phenyl}-methanol

Guidance literature:: Multi-step reaction with 2 steps

1: 75.5 percent / TiCl₄*2THF; Zn / tetrahydrofuran / 1.5 h / Heating

2: 93.5 percent / DIBAL-H / CH₂Cl₂; toluene / 4 h / -78 °C

With tetrachlorobis(tetrahydrofuran)titanium(IV); diisobutylaluminium hydride; zinc; In tetrahydrofuran; dichloromethane; toluene; 1: Condensation / 2: Reduction;
DOI:10.1021/jm990343b