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Benzoic acid, 3,3'-carbonylbis[5-chloro-6-methoxy-, dimethyl ester is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

154023-65-1

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154023-65-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 154023-65-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,4,0,2 and 3 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 154023-65:
(8*1)+(7*5)+(6*4)+(5*0)+(4*2)+(3*3)+(2*6)+(1*5)=101
101 % 10 = 1
So 154023-65-1 is a valid CAS Registry Number.

154023-65-1Relevant articles and documents

Investigation of the alkenyldiarylmethane non-nucleoside reverse transcriptase inhibitors as potential cAMP phosphodiesterase-4B2 inhibitors

Cullen, Matthew D.,Cheung, York-Fong,Houslay, Miles D.,Hartman, Tracy L.,Watson, Karen M.,Buckheit Jr., Robert W.,Pannecouque, Christophe,De Clercq, Erik,Cushman, Mark

, p. 1530 - 1533 (2008/09/19)

The alkenyldiarylmethanes (ADAMs) are currently being investigated as non-nucleoside HIV-1 reverse transcriptase inhibitors (NNRTIs) of potential value in the treatment of HIV infection and AIDS. During the course of these studies, a number of ADAM analog

Heterobifunctional pan-selectin inhibitors

-

Page/Page column 13, (2010/11/26)

Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-mediated function comprise particular glycomimetics alone or linked to a member of a class of compounds termed BASAs (Benzyl Amino Sulfonic Acids) or a member of a class of compounds termed BACAs (Benzyl Amino Carboxylic Acids).

HETEROBIFUNCTIONAL COMPOUNDS FOR SELECTIN INHIBITION

-

Page/Page column 26-27, (2008/06/13)

Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-mediated function comprise glycomimetics linked to a compound, for example a member of a class of compounds termed BASAs (Benzyl Amino Sulfonic Acids) or a member of a class of compounds termed BACAs (Benzyl Amino Carboxylic Acids).

Synthesis and biological activity of new diarylalkenes

Golebiewski,Wilkowska

, p. 759 - 766 (2007/10/03)

Condensation of 5-nitro-, 3-chloro-, and 5-chlorosalicylic acids with formaldehyde afforded dimeric disalicylmethanes, which were O-methylated with dimethyl sulfate and oxidized with chromium(VI) oxide to diarylketones 9, 10, 11, 12. Wittig reaction with

Studies directed toward a more potent cosalane pharmacophore: Synthesis of a substituted tetraphenylethylene which inhibits the cytopathic effect of HIV-1

Keyes, Robert F.,Cushman, Mark

, p. 372 - 376 (2007/10/03)

Tetra(3-carboxy-5-chloro-4-hydroxyphenyl)ethylene (6) was prepared by a modified McMurry coupling of 3,3′-dichloro-5,5′-di(methoxycarbonyl)-4,4′- dimethoxybenzophenone (9) in the presence of zinc and titanium tetrachloride in refluxing tetrahydrofuran, fo

Design, Synthesis, and Biological Evaluation of Cosalane, a Novel Anti-HIV Agent Which Inhibits Multiple Features of Virus Reproduction

Cushman, Mark,Golebiewski, W. Marek,McMahon, James B.,Buckheit, Robert W.,Clanton, David J.,et al.

, p. 3040 - 3050 (2007/10/02)

Cosalane (3), a novel anti-HIV agent having a disalicylmethane unit linked to C-3 of cholestane by a three-carbon linker, was synthesized from commercially available starting materials by a convergent route.Cosalane proved to be a potent inhibitor of HIV with a broad range of activity against a variety of laboratory, drug-resistant, and clinical HIV-1 isolates, HIV-2, and Rauscher murine leukemia virus.The cytotoxicity of cosalane is relatively low as reflected by an in vitro therapeutic index of > 100.Although cosalane inhibits HIV-1 reverse transcriptase and protease, time of addition experiments indicate that it prevents the cytopathic effect of HIV by acting earlier than reverse transcription in the viral replication cycle.The available evidence indicates that the primary mechanism of action of cosalane involves inhibition of gp 120-CD4 binding as well as inhibition of a postattachment event prior to reverse transcription.

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