2,2-bis(4-(trifluoromethyl)phenyl)-1,3,2λ⁴-oxazaborolidine

Base Information

• Chemical Name: 2,2-bis(4-(trifluoromethyl)phenyl)-1,3,2λ⁴-oxazaborolidine
• CAS No.: 1435463-69-6
• Molecular Formula: C₁₆H₁₄BF₆NO
• Molecular Weight: 361.095
• Mol file: 1435463-69-6.mol

Synonyms:2,2-bis(4-(trifluoromethyl)phenyl)-1,3,2λ⁴-oxazaborolidine

Chemical Property of 2,2-bis(4-(trifluoromethyl)phenyl)-1,3,2λ⁴-oxazaborolidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2-bis(4-(trifluoromethyl)phenyl)-1,3,2λ⁴-oxazaborolidine

There total 2 articles about 2,2-bis(4-(trifluoromethyl)phenyl)-1,3,2λ⁴-oxazaborolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

boric acid tributyl ester (688-74-4) + p-trifluoromethylphenyl bromide (402-43-7) + ethanolamine (141-43-5) → 2,2-bis(4-(trifluoromethyl)phenyl)-1,3,2λ4-oxazaborolidine (1435463-69-6)

Guidance literature:

p-trifluoromethylphenyl bromide; With n-butyllithium; In diethyl ether; hexane; at -78 ℃; for 0.5h;

boric acid tributyl ester; In diethyl ether; hexane; at -78 - 20 ℃;

ethanolamine; In ethanol; water; at 50 ℃; for 1h;

DOI:10.1055/s-0040-1707114

Reference yield:

ethanolamine (141-43-5) + hydroxybis(4-(trifluoromethyl)phenyl)borane → 2,2-bis(4-(trifluoromethyl)phenyl)-1,3,2λ4-oxazaborolidine (1435463-69-6)

Guidance literature:

In ethanol; water; at 20 - 50 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.bmc.2013.03.037

Reference yield: 96.0%

2,2-bis(4-(trifluoromethyl)phenyl)-1,3,2λ4-oxazaborolidine (1435463-69-6) → hydroxybis(4-(trifluoromethyl)phenyl)borane

Guidance literature:

With hydrogenchloride; In methanol; water; acetone; at 20 ℃; for 2h;

DOI:10.1055/s-0040-1707114

upstream raw materials:

ethanolamine

boric acid tributyl ester

p-trifluoromethylphenyl bromide