methyl (E)-2-<<(tert-butyl)amino>methyl>-3-(4-nitrophenyl)prop-2-enoate

Base Information

Chemical Name:methyl (E)-2-<<(tert-butyl)amino>methyl>-3-(4-nitrophenyl)prop-2-enoate
CAS No.:137104-45-1
Molecular Formula:C₁₅H₂₀N₂O₄
Molecular Weight:292.335
Hs Code.:

Synonyms:methyl (E)-2-<<(tert-butyl)amino>methyl>-3-(4-nitrophenyl)prop-2-enoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (E)-2-<<(tert-butyl)amino>methyl>-3-(4-nitrophenyl)prop-2-enoate

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Technology Process of methyl (E)-2-<<(tert-butyl)amino>methyl>-3-(4-nitrophenyl)prop-2-enoate

There total 2 articles about methyl (E)-2-<<(tert-butyl)amino>methyl>-3-(4-nitrophenyl)prop-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 137104-37-1
methyl (Z)-2-(bromomethyl)-3-(4-nitrophenyl)-2-propenoate

: 75-64-9
tert-butylamine

: 137104-45-1
methyl (E)-2-<<(tert-butyl)amino>methyl>-3-(4-nitrophenyl)prop-2-enoate

Guidance literature:: With potassium carbonate; In acetonitrile; for 24h; Ambient temperature;
DOI:10.1002/hlca.19910740608

Reference yield:

: 114106-93-3
methyl 2-[hydroxy(4-nitrophenyl)methyl]prop-2-enoate

: 137104-45-1
methyl (E)-2-<<(tert-butyl)amino>methyl>-3-(4-nitrophenyl)prop-2-enoate

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / 48percent aq. HBr, conc. H₂SO₄ / CH₂Cl₂ / Ambient temperature; overnight

2: 67 percent / K₂CO₃ / acetonitrile / 24 h / Ambient temperature

With sulfuric acid; hydrogen bromide; potassium carbonate; In dichloromethane; acetonitrile;
DOI:10.1002/hlca.19910740608

Reference yield:

: 137104-45-1
methyl (E)-2-<<(tert-butyl)amino>methyl>-3-(4-nitrophenyl)prop-2-enoate

: 137104-64-4
(E)-2-<(tert-butylamino)methyl>-3-(4-nitrophenyl)prop-2-enoic acid hydrochloride

Guidance literature:: methyl (E)-2-<<(tert-butyl)amino>methyl>-3-(4-nitrophenyl)prop-2-enoate; With water; sodium hydroxide; In ethanol; at 0 - 20 ℃; for 1h;

With hydrogenchloride; In water; Cooling with ice;
DOI:10.1002/hlca.19910740608