(1S,3R,4R,7aS)-methyl 1-(4-chlorophenyl)-4-(4-methoxyphenyl)-2,3,4,7a-tetrahydro-1H-cyclopenta[c]pyridine-3-carboxylate

Base Information

Chemical Name:(1S,3R,4R,7aS)-methyl 1-(4-chlorophenyl)-4-(4-methoxyphenyl)-2,3,4,7a-tetrahydro-1H-cyclopenta[c]pyridine-3-carboxylate
CAS No.:1422053-93-7
Molecular Formula:C₂₃H₂₂ClNO₃
Molecular Weight:395.886
Hs Code.:

Synonyms:(1S,3R,4R,7aS)-methyl 1-(4-chlorophenyl)-4-(4-methoxyphenyl)-2,3,4,7a-tetrahydro-1H-cyclopenta[c]pyridine-3-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S,3R,4R,7aS)-methyl 1-(4-chlorophenyl)-4-(4-methoxyphenyl)-2,3,4,7a-tetrahydro-1H-cyclopenta[c]pyridine-3-carboxylate

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Technology Process of (1S,3R,4R,7aS)-methyl 1-(4-chlorophenyl)-4-(4-methoxyphenyl)-2,3,4,7a-tetrahydro-1H-cyclopenta[c]pyridine-3-carboxylate

There total 1 articles about (1S,3R,4R,7aS)-methyl 1-(4-chlorophenyl)-4-(4-methoxyphenyl)-2,3,4,7a-tetrahydro-1H-cyclopenta[c]pyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 38068-98-3
6-(4-methoxyphenyl)fulvene

: 76862-09-4
methyl N-(4-chlorobenzylidene)glycinate

: 1422053-93-7
(1S,3R,4R,7aS)-methyl 1-(4-chlorophenyl)-4-(4-methoxyphenyl)-2,3,4,7a-tetrahydro-1H-cyclopenta[c]pyridine-3-carboxylate

: 1422053-94-8
(1S,3R,4S,7aS)-methyl 1-(4-chlorophenyl)-4-(4-methoxyphenyl)-2,3,4,7a-tetrahydro-1H-cyclopenta[c]pyridine-3-carboxylate

Guidance literature:: With tetrakis(acetonitrile)copper(I)tetrafluoroborate; (S)-TF-Biphamphos; caesium carbonate; In dichloromethane; at -10 ℃; enantioselective reaction; Inert atmosphere;
DOI:10.1002/anie.201208799

Reference yield: 92.0%

: 930-88-1
N-methylmaleimide

: 1422053-93-7
(1S,3R,4R,7aS)-methyl 1-(4-chlorophenyl)-4-(4-methoxyphenyl)-2,3,4,7a-tetrahydro-1H-cyclopenta[c]pyridine-3-carboxylate

: 1422054-04-3
(3aR,3bS,4R,5R,7S,7aS,8R,8aR)-methyl 7-(4-chlorophenyl)-4-(4-methoxyphenyl)-2-methyl-1,3-dioxo-2,3,3a,4,5,6,7,7a,8,8a-decahydro-1H-3b,8-ethenopyrrolo[3',4':3,4]cyclopenta[1,2-c]pyridine-5-carboxylate

Guidance literature:: In toluene; at 0 - 20 ℃; for 3h; enantioselective reaction; Inert atmosphere;
DOI:10.1002/anie.201208799

Reference yield:

: 1422053-93-7
(1S,3R,4R,7aS)-methyl 1-(4-chlorophenyl)-4-(4-methoxyphenyl)-2,3,4,7a-tetrahydro-1H-cyclopenta[c]pyridine-3-carboxylate

: 1422054-02-1
(1S,3R,4aR,7aS)-methyl 1-(4-chlorophenyl)-4-(4-methoxyphenyl)octahydro-1H-cyclopenta[c]pyridine-3-carboxylate

: (1S,3R,4aS,7aS)-methyl 1-(4-chlorophenyl)-4-(4-methoxyphenyl)octahydro-1H-cyclopenta[c]pyridine-3-carboxylate

Guidance literature:: With palladium on activated charcoal; hydrogen; In tetrahydrofuran; at 0 ℃; for 5h; under 15201 Torr; Overall yield = 90 %; diastereoselective reaction;
DOI:10.1002/anie.201208799