38068-98-3

Upstream product

• 542-92-7 cyclopenta-1,3-diene 
• 123-11-5 4-methoxy-benzaldehyde 
• 15719-64-9 methylammonium carbonate 
• 14774-77-7 p-methoxyphenyllithium 
• 68-12-2 N,N-dimethyl-formamide 
• 16733-97-4 cyclopentadienyllithium 
• 696-62-8 para-iodoanisole 
• 74-86-2 acetylene 
• 77-73-6 dicyclopentadiene 
• 136618-41-2 E-2'-p-methoxystyryl iodide 
• 1066-54-2 trimethylsilylacetylene 
• 130248-50-9 (E)-1,3-bis(trimethylsilyl)-6-(4-methoxyphenyl)fulvene 

Downstream Products

• 77988-77-3 5,6-Dihydro-4-(4-methoxybenzyl)-2-methyl-1,3-diphenyl-4H-cyclopentapyrrol 
• 77979-17-0 5,6,7,8-Tetrachlor-5',6'-dihydro-r-3-(4-methoxyphenyl)-2'-methyl-1',3'-diphenylspiro<1,4-benzodioxan-r-2,4'-<4H>cyclopentapyrrol> 
• 77979-17-0 5,6,7,8-Tetrachlor-5',6'-dihydro-r-3-(4-methoxyphenyl)-2'-methyl-1',3'-diphenylspiro<1,4-benzodioxan-s-2,4'-<4H>cyclopentapyrrol> 
• 1435450-54-6 [(4-methoxybenzyl)cyclopentadienyl]titanium trichloride 

Relevant academic research and scientific papers

Kinetics and Mechanism of Pyrrolidine Buffer-Catalyzed Fulvene Formation

Rapid synthesis of fulvenes is achieved using pyrrolidinium/pyrrolidine buffers in anhydrous acetonitrile. Time-dependent UV-vis absorption and NMR spectroscopy reveal that the rate and yield of fulvene formation depend strongly on both the presence of acid in the medium and the choice of solvent, and they are negatively affected by water. Kinetic data have been collected for various substrates, and the synthetic benefits of the adjusted reaction conditions are showcased. Enhancements of reaction rates are found in comparison to literature procedures. α-Unsaturated fulvenes that were previously difficult to access can now be obtained in good yields.

Synthesis & antitumor activity of new group 3 Metallocene complexes

The quest for alternative drugs with respect to the well-known cis-platin and its derivatives, which are still used in more than 50% of the treatment regimens for patients suffering from cancer, is highly needed. In this context, organometallic compounds, which are defined as metal complexes containing at least one direct covalent metal-carbon bond, have recently been found to be promising anticancer drug candidates. A series of new metallocene complexes with scandium, yttrium, and neodymium have been prepared and characterized. Some of these compounds show a very interesting anti-proliferative activity in triple negative breast cancer cell line (MDA.MB231) and the non-hormone sensitive prostate cancer cell line (DU145). Moreover, the interaction of some of them with biological membranes, evaluated using liposomes as bio-membrane mimetic model systems, seems to be relevant. The biological activity of these compounds, particularly those based on yttrium, already effective at low concentrations on both cancer cell lines, should be taken into account with regard to new therapeutic approaches in anticancer therapy.

GROUP 3 METAL COMPOUNDS AND USE THEREOF IN THE TREATMENT OF SOLID TUMORS

The present invention relates to the compounds of Formula 1 wherein M is Sc or Y, Hal is CI, Br, F or I R is alkyl with 1 - 4 atoms of C X is CI, Br, F or I or a group such as that shown hereinafter wherein R is alkyl with 1 - 4 atoms of C and the use thereof in the treatment of solid tumors.

Reaction discovery using acetylene gas as the chemical feedstock accelerated by the stop-flow micro-tubing reactor system

Acetylene gas has been applied as a feedstock under transition-metal catalysis and photo-redox conditions to produce important chemicals including terminal alkynes, fulvenes, and fluorinated styrene compounds. The reaction discovery process was accelerated through the use of stop-flow micro-tubing reactors. This reactor prototype was developed by joining elements from both continuous micro-flow and conventional batch reactors, which was convenient and effective for gas/liquid reaction screening. Notably, the developed transformations were either inefficient or unsuccessful in conventional batch reactors. Its success relies on the unique advantages provided by this stop-flow micro-tubing reactor system.

Asymmetric Pentafulvene Carbometalation - Access to Enantiopure Titanocene Dichlorides of Biological Relevance

Unprecedented asymmetric copper-catalyzed addition of ZnEt2 (ZnBu2) to the exocyclic C=C bond of pentafulvenes C5H4(=CHAr) (Ar=2-MeOPh and related species) results in enantiomerically enriched (up to 93:7 e.r.)

Ring-functionalized niobocene complexes

A series of new ring-functionalized niobocene dichloride compounds (RCH2C5H4)2NbCl2 (R = MeOCH2, (CH2)5NCH2, 2-MeOC 6H4, 3-MeOC6

Synthesis, characterization and cytotoxic activity on breast cancer cells of new half-titanocene derivatives

A series of novel titanocene-complexes has been prepared and evaluated for their growth regulatory effects in MCF7 and SkBr3 breast cancer cells. The capability of some of these compound to elicit relevant repressive effects on cancer cell growth could be taken into account towards novel pharmacological approaches in cancer therapy.

An efficient catalytic method for fulvene synthesis

The effects of the nature and amount of base, substrate structure, amount of added water and solvent on the condensation of carbonyl compounds with cyclopentadiene in the presence of secondary amines were investigated. Based on these studies, a new efficient and green synthesis of fulvenes was developed.

Tandem Reactions of N,N-Dialkylamides with Organolithium Compounds and Cyclopentadiene. A New Efficient Synthesis of Pentafulvenes

Reactions of N,N-dialkylamides with organolithium compounds followed by addition of cyclopentadiene furnish 6-mono- or 6,6-di-substituted pentafulvenes in moderate to high yields, providing a new and simple pentafulvene synthesis.

A new synthesis of substituted fulvenes

A new fulvene synthesis results from the palladium-catalyzed [2 + 2 + 2] annulation of 1 mol of a β-substituted vinyl iodide and 2 mol of a monosubstituted acetylene. This variant of the Heck reaction tolerates a wide range of substrate substituents with