4-{(2,3-bis-methoxycarbonyloxy-benzoyl)-[3-(8-methoxycarbonyloxy-2,4-dioxo-4H-benzo[e][1,3]oxazin-3-yl)-propyl]-amino}-pentanoic acid

Base Information

Chemical Name:4-{(2,3-bis-methoxycarbonyloxy-benzoyl)-[3-(8-methoxycarbonyloxy-2,4-dioxo-4H-benzo[e][1,3]oxazin-3-yl)-propyl]-amino}-pentanoic acid
CAS No.:439216-95-2
Molecular Formula:C₂₉H₃₀N₂O₁₅
Molecular Weight:646.562
Hs Code.:

4-{(2,3-bis-methoxycarbonyloxy-benzoyl)-[3-(8-methoxycarbonyloxy-2,4-dioxo-4<i>H</i>-benzo[<i>e</i>][1,3]oxazin-3-yl)-propyl]-amino}-pentanoic acid

Synonyms:4-{(2,3-bis-methoxycarbonyloxy-benzoyl)-[3-(8-methoxycarbonyloxy-2,4-dioxo-4H-benzo[e][1,3]oxazin-3-yl)-propyl]-amino}-pentanoic acid

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Chemical Property of 4-{(2,3-bis-methoxycarbonyloxy-benzoyl)-[3-(8-methoxycarbonyloxy-2,4-dioxo-4H-benzo[e][1,3]oxazin-3-yl)-propyl]-amino}-pentanoic acid

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Technology Process of 4-{(2,3-bis-methoxycarbonyloxy-benzoyl)-[3-(8-methoxycarbonyloxy-2,4-dioxo-4H-benzo[e][1,3]oxazin-3-yl)-propyl]-amino}-pentanoic acid

There total 3 articles about 4-{(2,3-bis-methoxycarbonyloxy-benzoyl)-[3-(8-methoxycarbonyloxy-2,4-dioxo-4H-benzo[e][1,3]oxazin-3-yl)-propyl]-amino}-pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 201296-89-1
(2,3-dimethoxycarbonyloxy)benzoyl chloride

: 439216-77-0
N-(aminopropyl)-4-aminovaleric acid

: 439216-95-2
4-{(2,3-bis-methoxycarbonyloxy-benzoyl)-[3-(8-methoxycarbonyloxy-2,4-dioxo-4H-benzo[e][1,3]oxazin-3-yl)-propyl]-amino}-pentanoic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; at 0 - 5 ℃; for 1h;
DOI:10.1021/jm010546b

Reference yield:

: 303-38-8
2,3-Dihydroxybenzoic acid

: 439216-95-2
4-{(2,3-bis-methoxycarbonyloxy-benzoyl)-[3-(8-methoxycarbonyloxy-2,4-dioxo-4H-benzo[e][1,3]oxazin-3-yl)-propyl]-amino}-pentanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide

2: PCl₅ / CCl₄

3: 60 percent / aq. sodium hydroxide / tetrahydrofuran / 1 h / 0 - 5 °C

With sodium hydroxide; phosphorus pentachloride; In tetrahydrofuran; tetrachloromethane;
DOI:10.1021/jm010546b

Reference yield:

: 123-76-2
levulinic acid

: 439216-95-2
4-{(2,3-bis-methoxycarbonyloxy-benzoyl)-[3-(8-methoxycarbonyloxy-2,4-dioxo-4H-benzo[e][1,3]oxazin-3-yl)-propyl]-amino}-pentanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanol

1.2: 70 percent / 10percent Pd/C; H₂ / methanol / 20 °C / atmospheric pressure

2.1: 60 percent / aq. sodium hydroxide / tetrahydrofuran / 1 h / 0 - 5 °C

With sodium hydroxide; In tetrahydrofuran; methanol;
DOI:10.1021/jm010546b