tert-butyl (R,R)-2-[N(1')-(p-methoxybenzyl)piperidin-2'-yl]-5-(tert-butyldimethylsiloxy)pentanoate

Base Information

Chemical Name:tert-butyl (R,R)-2-[N(1')-(p-methoxybenzyl)piperidin-2'-yl]-5-(tert-butyldimethylsiloxy)pentanoate
CAS No.:1619924-93-4
Molecular Formula:C₂₈H₄₉NO₄Si
Molecular Weight:491.787
Hs Code.:

Synonyms:tert-butyl (R,R)-2-[N(1')-(p-methoxybenzyl)piperidin-2'-yl]-5-(tert-butyldimethylsiloxy)pentanoate

Suppliers and Price of tert-butyl (R,R)-2-[N(1')-(p-methoxybenzyl)piperidin-2'-yl]-5-(tert-butyldimethylsiloxy)pentanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl (R,R)-2-[N(1')-(p-methoxybenzyl)piperidin-2'-yl]-5-(tert-butyldimethylsiloxy)pentanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl (R,R)-2-[N(1')-(p-methoxybenzyl)piperidin-2'-yl]-5-(tert-butyldimethylsiloxy)pentanoate

There total 7 articles about tert-butyl (R,R)-2-[N(1')-(p-methoxybenzyl)piperidin-2'-yl]-5-(tert-butyldimethylsiloxy)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1619924-92-3
tert-butyl (R)-2-[N(1')-(p-methoxybenzyl)piperidin-2'-yl]acetate

: 78878-05-4
1-iodo-3-(tert-butyldimethylsilyloxy)propane

: 1619924-93-4
tert-butyl (R,R)-2-[N(1')-(p-methoxybenzyl)piperidin-2'-yl]-5-(tert-butyldimethylsiloxy)pentanoate

Guidance literature:: tert-butyl (R)-2-[N(1')-(p-methoxybenzyl)piperidin-2'-yl]acetate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

1-iodo-3-(tert-butyldimethylsilyloxy)propane; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;
DOI:10.1039/c4cc02135e

Reference yield:

: 27784-76-5
tert-butyl diethylphosphonoacetate

: 1619924-93-4
tert-butyl (R,R)-2-[N(1')-(p-methoxybenzyl)piperidin-2'-yl]-5-(tert-butyldimethylsiloxy)pentanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: diisobutylaluminium hydride; n-butyllithium / tetrahydrofuran / 16 h / -78 - 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

2.2: 2 h / -78 °C / Inert atmosphere

3.1: iodine; 1H-imidazole; triphenylphosphine / acetonitrile / 16 h / 80 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

4.2: -78 - 20 °C / Inert atmosphere

With 1H-imidazole; n-butyllithium; iodine; diisobutylaluminium hydride; triphenylphosphine; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; acetonitrile;
DOI:10.1039/c4cc02135e

Reference yield:

: 117471-84-8
1,1-dimethylethyl (E)-7-hydroxyhept-2-enoate

: 1619924-93-4
tert-butyl (R,R)-2-[N(1')-(p-methoxybenzyl)piperidin-2'-yl]-5-(tert-butyldimethylsiloxy)pentanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

1.2: 2 h / -78 °C / Inert atmosphere

2.1: iodine; 1H-imidazole; triphenylphosphine / acetonitrile / 16 h / 80 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

3.2: -78 - 20 °C / Inert atmosphere

With 1H-imidazole; n-butyllithium; iodine; triphenylphosphine; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; acetonitrile;
DOI:10.1039/c4cc02135e