tert-butyl (R,R)-3-[N-(p-methoxybenzyl)-N-(α-methyl-p-methoxybenzyl)amino]-7-chloroheptanoate

Base Information

Chemical Name:tert-butyl (R,R)-3-[N-(p-methoxybenzyl)-N-(α-methyl-p-methoxybenzyl)amino]-7-chloroheptanoate
CAS No.:1619924-90-1
Molecular Formula:C₂₈H₄₀ClNO₄
Molecular Weight:490.083
Hs Code.:

Synonyms:tert-butyl (R,R)-3-[N-(p-methoxybenzyl)-N-(α-methyl-p-methoxybenzyl)amino]-7-chloroheptanoate

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Chemical Property of tert-butyl (R,R)-3-[N-(p-methoxybenzyl)-N-(α-methyl-p-methoxybenzyl)amino]-7-chloroheptanoate

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Technology Process of tert-butyl (R,R)-3-[N-(p-methoxybenzyl)-N-(α-methyl-p-methoxybenzyl)amino]-7-chloroheptanoate

There total 4 articles about tert-butyl (R,R)-3-[N-(p-methoxybenzyl)-N-(α-methyl-p-methoxybenzyl)amino]-7-chloroheptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: (R)-N-(p-methoxybenzyl)-N-(α-methyl-p-methoxybenzyl)amine

: tert-butyl (E)-7-chlorohept-2-enoate

: 1619924-90-1
tert-butyl (R,R)-3-[N-(p-methoxybenzyl)-N-(α-methyl-p-methoxybenzyl)amino]-7-chloroheptanoate

Guidance literature:: (R)-N-(p-methoxybenzyl)-N-(α-methyl-p-methoxybenzyl)amine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

tert-butyl (E)-7-chlorohept-2-enoate; In tetrahydrofuran; hexane; at -78 ℃; for 2h; Inert atmosphere;
DOI:10.1039/c4cc02135e

Reference yield:

: 542-28-9,26354-94-9
3,4,5,6-tetrahydro-2H-pyran-2-one

: 1619924-90-1
tert-butyl (R,R)-3-[N-(p-methoxybenzyl)-N-(α-methyl-p-methoxybenzyl)amino]-7-chloroheptanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: diisobutylaluminium hydride; n-butyllithium / tetrahydrofuran / 16 h / -78 - 20 °C / Inert atmosphere

2.1: triphenylphosphine; triethylamine; tetrachloromethane / acetonitrile / 24 h / Reflux

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

3.2: 2 h / -78 °C / Inert atmosphere

With tetrachloromethane; n-butyllithium; diisobutylaluminium hydride; triethylamine; triphenylphosphine; In tetrahydrofuran; hexane; acetonitrile;
DOI:10.1039/c4cc02135e

Reference yield:

: 27784-76-5
tert-butyl diethylphosphonoacetate

: 1619924-90-1
tert-butyl (R,R)-3-[N-(p-methoxybenzyl)-N-(α-methyl-p-methoxybenzyl)amino]-7-chloroheptanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: diisobutylaluminium hydride; n-butyllithium / tetrahydrofuran / 16 h / -78 - 20 °C / Inert atmosphere

2.1: triphenylphosphine; triethylamine; tetrachloromethane / acetonitrile / 24 h / Reflux

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

3.2: 2 h / -78 °C / Inert atmosphere

With tetrachloromethane; n-butyllithium; diisobutylaluminium hydride; triethylamine; triphenylphosphine; In tetrahydrofuran; hexane; acetonitrile;
DOI:10.1039/c4cc02135e