(2S,3R)-2-((R)-1-Hydroxy-ethyl)-3-((R)-1-phenyl-ethylamino)-pent-4-enoic acid tert-butyl ester

Base Information

Chemical Name:(2S,3R)-2-((R)-1-Hydroxy-ethyl)-3-((R)-1-phenyl-ethylamino)-pent-4-enoic acid tert-butyl ester
CAS No.:188945-54-2
Molecular Formula:C₁₉H₂₉NO₃
Molecular Weight:319.444
Hs Code.:

Synonyms:(2S,3R)-2-((R)-1-Hydroxy-ethyl)-3-((R)-1-phenyl-ethylamino)-pent-4-enoic acid tert-butyl ester

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Chemical Property of (2S,3R)-2-((R)-1-Hydroxy-ethyl)-3-((R)-1-phenyl-ethylamino)-pent-4-enoic acid tert-butyl ester

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Technology Process of (2S,3R)-2-((R)-1-Hydroxy-ethyl)-3-((R)-1-phenyl-ethylamino)-pent-4-enoic acid tert-butyl ester

There total 5 articles about (2S,3R)-2-((R)-1-Hydroxy-ethyl)-3-((R)-1-phenyl-ethylamino)-pent-4-enoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 169764-33-4
(2S,3R)-3-[Allyl-((R)-1-phenyl-ethyl)-amino]-2-((R)-1-hydroxy-ethyl)-pent-4-enoic acid tert-butyl ester

: 188945-54-2
(2S,3R)-2-((R)-1-Hydroxy-ethyl)-3-((R)-1-phenyl-ethylamino)-pent-4-enoic acid tert-butyl ester

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-dimethylbarbituric acid;
DOI:10.1039/a700216e

Reference yield:

: 21651-12-7
(E)-2,4-pentadienoic acid

: 188945-54-2
(2S,3R)-2-((R)-1-Hydroxy-ethyl)-3-((R)-1-phenyl-ethylamino)-pent-4-enoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: conc. H₂SO₄

2: 87 percent

3: LDA / tetrahydrofuran / 1.) 0 deg C, 2 h, 2.) -78 deg C

4: 98 percent / Pd(PPh₃)4, N,N-dimethylbarbituric acid

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-dimethylbarbituric acid; sulfuric acid; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1039/a700216e

Reference yield:

: 16809-92-0
tert-butyl (2E)-penta-2,4-dienoate

: 188945-54-2
(2S,3R)-2-((R)-1-Hydroxy-ethyl)-3-((R)-1-phenyl-ethylamino)-pent-4-enoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent

2: LDA / tetrahydrofuran / 1.) 0 deg C, 2 h, 2.) -78 deg C

3: 98 percent / Pd(PPh₃)4, N,N-dimethylbarbituric acid

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-dimethylbarbituric acid; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1039/a700216e