(2S,3R)-2-((R)-1-Hydroxy-ethyl)-3-((R)-1-phenyl-ethylamino)-pent-4-enoic acid

Base Information

Chemical Name:(2S,3R)-2-((R)-1-Hydroxy-ethyl)-3-((R)-1-phenyl-ethylamino)-pent-4-enoic acid
CAS No.:188945-52-0
Molecular Formula:C₁₅H₂₁NO₃
Molecular Weight:263.337
Hs Code.:

Synonyms:(2S,3R)-2-((R)-1-Hydroxy-ethyl)-3-((R)-1-phenyl-ethylamino)-pent-4-enoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3R)-2-((R)-1-Hydroxy-ethyl)-3-((R)-1-phenyl-ethylamino)-pent-4-enoic acid

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Technology Process of (2S,3R)-2-((R)-1-Hydroxy-ethyl)-3-((R)-1-phenyl-ethylamino)-pent-4-enoic acid

There total 7 articles about (2S,3R)-2-((R)-1-Hydroxy-ethyl)-3-((R)-1-phenyl-ethylamino)-pent-4-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 188945-54-2
(2S,3R)-2-((R)-1-Hydroxy-ethyl)-3-((R)-1-phenyl-ethylamino)-pent-4-enoic acid tert-butyl ester

: 188945-52-0
(2S,3R)-2-((R)-1-Hydroxy-ethyl)-3-((R)-1-phenyl-ethylamino)-pent-4-enoic acid

Guidance literature:: With trifluoroacetic acid;
DOI:10.1039/a700216e

Reference yield: 92.0%

: (4R,5S,6R)-2-Ethyl-6-methyl-3-((R)-1-phenyl-ethyl)-4-vinyl-[1,3]oxazinane-5-carboxylic acid tert-butyl ester

: 188945-52-0
(2S,3R)-2-((R)-1-Hydroxy-ethyl)-3-((R)-1-phenyl-ethylamino)-pent-4-enoic acid

Guidance literature:: With hydrogenchloride;
DOI:10.1039/a700216e

Reference yield:

: 21651-12-7
(E)-2,4-pentadienoic acid

: 188945-52-0
(2S,3R)-2-((R)-1-Hydroxy-ethyl)-3-((R)-1-phenyl-ethylamino)-pent-4-enoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: conc. H₂SO₄

2: 87 percent

3: LDA / tetrahydrofuran / 1.) 0 deg C, 2 h, 2.) -78 deg C

4: 98 percent / Pd(PPh₃)4, N,N-dimethylbarbituric acid

5: 97 percent / TFA

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-dimethylbarbituric acid; sulfuric acid; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1039/a700216e