methanesulfonic acid (1R,2R,6R)-6-isopropyl-2-[(2S,3R)-2-methoxymethoxy-3-(4-methoxyphenoxy)-pent-4-enyl]-3-methyl-cyclohex-3-enylmethyl ester

Base Information

• Chemical Name: methanesulfonic acid (1R,2R,6R)-6-isopropyl-2-[(2S,3R)-2-methoxymethoxy-3-(4-methoxyphenoxy)-pent-4-enyl]-3-methyl-cyclohex-3-enylmethyl ester
• CAS No.: 849122-82-3
• Molecular Formula: C₂₆H₄₀O₇S
• Molecular Weight: 496.665
• Mol file: 849122-82-3.mol

Synonyms:methanesulfonic acid (1R,2R,6R)-6-isopropyl-2-[(2S,3R)-2-methoxymethoxy-3-(4-methoxyphenoxy)-pent-4-enyl]-3-methyl-cyclohex-3-enylmethyl ester

Chemical Property of methanesulfonic acid (1R,2R,6R)-6-isopropyl-2-[(2S,3R)-2-methoxymethoxy-3-(4-methoxyphenoxy)-pent-4-enyl]-3-methyl-cyclohex-3-enylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methanesulfonic acid (1R,2R,6R)-6-isopropyl-2-[(2S,3R)-2-methoxymethoxy-3-(4-methoxyphenoxy)-pent-4-enyl]-3-methyl-cyclohex-3-enylmethyl ester

There total 6 articles about methanesulfonic acid (1R,2R,6R)-6-isopropyl-2-[(2S,3R)-2-methoxymethoxy-3-(4-methoxyphenoxy)-pent-4-enyl]-3-methyl-cyclohex-3-enylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

{(1R,2R,6R)-6-isopropyl-2-[(2S,3R)-2-methoxymethoxy-3-(4-methoxyphenoxy)-pent-4-enyl]-3-methyl-cyclohex-3-enyl}-methanol (848760-90-7) + methanesulfonyl chloride (124-63-0) → methanesulfonic acid (1R,2R,6R)-6-isopropyl-2-[(2S,3R)-2-methoxymethoxy-3-(4-methoxyphenoxy)-pent-4-enyl]-3-methyl-cyclohex-3-enylmethyl ester (849122-82-3)

Guidance literature:

With TEA; In dichloromethane; at 0 - 25 ℃;

DOI:10.1016/j.tet.2004.12.039 DOI:10.1002/chem.200500749

Reference yield:

(1R,2R,6R)-6-isopropyl-2-[(2S,3R)-2-methoxymethoxy-3-(4-methoxyphenoxy)-pent-4-enyl]-3-methyl-cyclohex-3-enecarbaldehyde (849122-81-2) → methanesulfonic acid (1R,2R,6R)-6-isopropyl-2-[(2S,3R)-2-methoxymethoxy-3-(4-methoxyphenoxy)-pent-4-enyl]-3-methyl-cyclohex-3-enylmethyl ester (849122-82-3)

Guidance literature:

Multi-step reaction with 2 steps

1: NaBH₄ / ethanol / 25 °C

2: 95 percent / TEA / CH₂Cl₂ / 0 - 25 °C

With sodium tetrahydroborate; TEA; In ethanol; dichloromethane;

DOI:10.1002/chem.200500749

Reference yield:

(2S,3R)-1-[(1R,5R,6R)-6-dimethoxymethyl-5-isopropyl-2-methyl-cyclohex-2-enyl]3-(4-methoxyphenoxy)-pent-4-en-2-ol (848760-88-3) → methanesulfonic acid (1R,2R,6R)-6-isopropyl-2-[(2S,3R)-2-methoxymethoxy-3-(4-methoxyphenoxy)-pent-4-enyl]-3-methyl-cyclohex-3-enylmethyl ester (849122-82-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 95 percent / DIPEA; TBAI / CH₂Cl₂ / 25 °C

2: aq. LiBF₄ / acetonitrile / 25 °C

3: NaBH₄ / ethanol / 25 °C

4: 95 percent / TEA / CH₂Cl₂ / 0 - 25 °C

With sodium tetrahydroborate; lithium tetrafluoroborate; TEA; tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; acetonitrile;

DOI:10.1002/chem.200500749

upstream raw materials:

{(1R,2R,6R)-6-isopropyl-2-[(2S,3R)-2-methoxymethoxy-3-(4-methoxyphenoxy)-pent-4-enyl]-3-methyl-cyclohex-3-enyl}-methanol

methanesulfonyl chloride

(2S,3R)-1-[(1R,5R,6R)-6-dimethoxymethyl-5-isopropyl-2-methyl-cyclohex-2-enyl]3-(4-methoxyphenoxy)-pent-4-en-2-ol

(1R,2R,6R)-6-isopropyl-2-[(2S,3R)-2-methoxymethoxy-3-(4-methoxyphenoxy)-pent-4-enyl]-3-methyl-cyclohex-3-enecarbaldehyde

Downstream raw materials:

{(1R,2R,6R)-6-isopropyl-2-[(2S,3R)-2-methoxymethoxy-3-(4-methoxyphenoxy)-pent-4-enyl]-3-methyl-cyclohex-3-enyl}-acetonitrile

{(1R,2R,6R)-6-isopropyl-2-[(2S,3R)-2-methoxymethoxy-3-(4-methoxyphenoxy)-pent-4-enyl]-3-methyl-cyclohex-3-enyl}-acetaldehyde

(2R,3S)-1-{(1R,2R,6R)-6-isopropyl-2-[(2S,3R)-2-methoxymethoxy-3-(4-methoxyphenoxy)pent-4-enyl]-3-methylcyclohex-3-enyl}-3-(4-methoxyphenoxy)pent-4-en-2-ol

(2R,3R)-1-{(1R,2R,6R)-6-isopropyl-2-[(2S,3R)-2-methoxymethoxy-3-(4-methoxyphenoxy)pent-4-enyl]-3-methylcyclohex-3-enyl}-3-(4-methoxyphenoxy)pent-4-en-2-ol