1-[(5-Benzoyl-2-piperidin-1-yl-thiazol-4-ylcarbamoyl)-methyl]-3,5,7-triaza-1-azonia-tricyclo[3.3.1.1^3,7]decane; chloride

Base Information

• Chemical Name: 1-[(5-Benzoyl-2-piperidin-1-yl-thiazol-4-ylcarbamoyl)-methyl]-3,5,7-triaza-1-azonia-tricyclo[3.3.1.1^3,7]decane; chloride
• CAS No.: 72100-72-2
• Molecular Formula: C₂₃H₃₀N₇O₂S*Cl
• Molecular Weight: 504.056

Synonyms:1-[(5-Benzoyl-2-piperidin-1-yl-thiazol-4-ylcarbamoyl)-methyl]-3,5,7-triaza-1-azonia-tricyclo[3.3.1.1^3,7]decane; chloride

Chemical Property of 1-[(5-Benzoyl-2-piperidin-1-yl-thiazol-4-ylcarbamoyl)-methyl]-3,5,7-triaza-1-azonia-tricyclo[3.3.1.1^3,7]decane; chloride

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Technology Process of 1-[(5-Benzoyl-2-piperidin-1-yl-thiazol-4-ylcarbamoyl)-methyl]-3,5,7-triaza-1-azonia-tricyclo[3.3.1.1^3,7]decane; chloride

There total 2 articles about 1-[(5-Benzoyl-2-piperidin-1-yl-thiazol-4-ylcarbamoyl)-methyl]-3,5,7-triaza-1-azonia-tricyclo[3.3.1.1^3,7]decane; chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.9%

hexamethylenetetramine (100-97-0) + N-(5-Benzoyl-2-piperidin-1-yl-thiazol-4-yl)-2-chloro-acetamide (72100-71-1) → 1-[(5-Benzoyl-2-piperidin-1-yl-thiazol-4-ylcarbamoyl)-methyl]-3,5,7-triaza-1-azonia-tricyclo[3.3.1.13,7]decane; chloride (72100-72-2)

Guidance literature:

hydrogenchloride; In methanol; water; at 50 ℃; for 4h; Heating;

DOI:10.1021/jo01290a010

Reference yield:

4-amino-5-benzoyl-2-(1-piperidinyl)-1,3-thiazole (72100-52-8) → 1-[(5-Benzoyl-2-piperidin-1-yl-thiazol-4-ylcarbamoyl)-methyl]-3,5,7-triaza-1-azonia-tricyclo[3.3.1.13,7]decane; chloride (72100-72-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / K₂CO₃ / benzene / 1 h / Heating

2: 81.9 percent / HCl / methanol; H₂O / 4 h / 50 °C / Heating

With potassium carbonate; hydrogenchloride; In methanol; water; benzene;

DOI:10.1021/jo01290a010

Reference yield:

1-[(5-Benzoyl-2-piperidin-1-yl-thiazol-4-ylcarbamoyl)-methyl]-3,5,7-triaza-1-azonia-tricyclo[3.3.1.13,7]decane; chloride (72100-72-2) → 2-Amino-N-(5-benzoyl-2-piperidin-1-yl-thiazol-4-yl)-acetamide; hydrochloride (72100-73-3)

Guidance literature:

With hydrogenchloride; In methanol; at 50 ℃; for 4h;

DOI:10.1021/jo01290a010

upstream raw materials:

hexamethylenetetramine

N-(5-Benzoyl-2-piperidin-1-yl-thiazol-4-yl)-2-chloro-acetamide

4-amino-5-benzoyl-2-(1-piperidinyl)-1,3-thiazole

Downstream raw materials:

2-Amino-N-(5-benzoyl-2-piperidin-1-yl-thiazol-4-yl)-acetamide; hydrochloride

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