(5-chloro-2-cyclopropylethynylphenyl)phosphonic acid monoethyl ester

Base Information

• Chemical Name: (5-chloro-2-cyclopropylethynylphenyl)phosphonic acid monoethyl ester
• CAS No.: 639517-13-8
• Molecular Formula: C₁₃H₁₄ClO₃P
• Molecular Weight: 284.679
• Mol file: 639517-13-8.mol

Synonyms:(5-chloro-2-cyclopropylethynylphenyl)phosphonic acid monoethyl ester

Chemical Property of (5-chloro-2-cyclopropylethynylphenyl)phosphonic acid monoethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (5-chloro-2-cyclopropylethynylphenyl)phosphonic acid monoethyl ester

There total 2 articles about (5-chloro-2-cyclopropylethynylphenyl)phosphonic acid monoethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(5-chloro-2-cyclopropylethynyl-phenyl)-phosphonic acid diethyl ester (639517-01-4) → (5-chloro-2-cyclopropylethynylphenyl)phosphonic acid monoethyl ester (639517-13-8)

Guidance literature:

With sodium hydroxide; In ethanol; Heating;

DOI:10.1021/ja038627f

Reference yield:

4-chloro-2-(diethoxyphosphonyl)phenyl 1,1,2,2-tetra-fluoro-2-(1,1,2,2-tetrafluoroethoxy)ethanesulfonate (639516-89-5) → (5-chloro-2-cyclopropylethynylphenyl)phosphonic acid monoethyl ester (639517-13-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / PdCl₂(PPh₃)2; Et₃N / dimethylformamide / 5 h / 80 °C

2: 93 percent / aq. NaOH / ethanol / Heating

With bis-triphenylphosphine-palladium(II) chloride; sodium hydroxide; triethylamine; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/ja038627f

Reference yield:

(5-chloro-2-cyclopropylethynylphenyl)phosphonic acid monoethyl ester (639517-13-8) → C13H13Cl2O2P

Guidance literature:

With thionyl chloride; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1021/jo0614644

upstream raw materials:

(5-chloro-2-cyclopropylethynyl-phenyl)-phosphonic acid diethyl ester

4-chloro-2-(diethoxyphosphonyl)phenyl 1,1,2,2-tetra-fluoro-2-(1,1,2,2-tetrafluoroethoxy)ethanesulfonate

Downstream raw materials:

N-benzyl (5-chloro-2-cyclopropylethynyl-phenyl)phosphonamide monoethyl ester