1-{4-[2-(2-methyl-3H-imidazol-4-yl)-8-phenyl-purin-9-yl]-phenyl}-cyclobutylamine

Base Information

Chemical Name:1-{4-[2-(2-methyl-3H-imidazol-4-yl)-8-phenyl-purin-9-yl]-phenyl}-cyclobutylamine
CAS No.:1439392-03-6
Molecular Formula:C₂₅H₂₃N₇
Molecular Weight:421.505
Hs Code.:

Synonyms:1-{4-[2-(2-methyl-3H-imidazol-4-yl)-8-phenyl-purin-9-yl]-phenyl}-cyclobutylamine

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Chemical Property of 1-{4-[2-(2-methyl-3H-imidazol-4-yl)-8-phenyl-purin-9-yl]-phenyl}-cyclobutylamine

Chemical Property:

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Technology Process of 1-{4-[2-(2-methyl-3H-imidazol-4-yl)-8-phenyl-purin-9-yl]-phenyl}-cyclobutylamine

There total 5 articles about 1-{4-[2-(2-methyl-3H-imidazol-4-yl)-8-phenyl-purin-9-yl]-phenyl}-cyclobutylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1439392-05-8
[1-(4-{2-[2-methyl-3-(2-trimethylsilanyl-ethoxymethyl)-3H-imidazol-4-yl]-8-phenyl-purin-9-yl}-phenyl)-cyclobutyl]-carbamic acid tert-butyl ester

: 1439392-03-6
1-{4-[2-(2-methyl-3H-imidazol-4-yl)-8-phenyl-purin-9-yl]-phenyl}-cyclobutylamine

Guidance literature:: With hydrogenchloride; water; In methanol; at 80 ℃; for 2h; Inert atmosphere;

Reference yield:

: 1439391-55-5
{1-[4-(2-chloro-8-phenyl-purin-9-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester

: 1439392-03-6
1-{4-[2-(2-methyl-3H-imidazol-4-yl)-8-phenyl-purin-9-yl]-phenyl}-cyclobutylamine

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; 1,4-dioxane / 0.83 h / 120 °C / Inert atmosphere; Microwave irradiation

2: hydrogenchloride; water / methanol / 2 h / 80 °C / Inert atmosphere

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; In tetrahydrofuran; 1,4-dioxane; methanol;

Reference yield:

: 1259224-00-4
[1-(4-amino-phenyl)-cyclobutyl]-carbamic acid tert-butyl ester

: 1439392-03-6
1-{4-[2-(2-methyl-3H-imidazol-4-yl)-8-phenyl-purin-9-yl]-phenyl}-cyclobutylamine

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere

2: hydrogen / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

3: copper diacetate / 2 h / 100 °C / Inert atmosphere

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; 1,4-dioxane / 0.83 h / 120 °C / Inert atmosphere; Microwave irradiation

5: hydrogenchloride; water / methanol / 2 h / 80 °C / Inert atmosphere

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; hydrogen; copper diacetate; In tetrahydrofuran; 1,4-dioxane; methanol;