(5-benzylhexahydropyrrolo[3,4-c]pyrrol-2-yl)-(4,6-dimethylpyrimidin-5-yl)methanone

Base Information

Chemical Name:(5-benzylhexahydropyrrolo[3,4-c]pyrrol-2-yl)-(4,6-dimethylpyrimidin-5-yl)methanone
CAS No.:872001-73-5
Molecular Formula:C₂₀H₂₄N₄O
Molecular Weight:336.437
Hs Code.:

Synonyms:(5-benzylhexahydropyrrolo[3,4-c]pyrrol-2-yl)-(4,6-dimethylpyrimidin-5-yl)methanone

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Chemical Property of (5-benzylhexahydropyrrolo[3,4-c]pyrrol-2-yl)-(4,6-dimethylpyrimidin-5-yl)methanone

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Technology Process of (5-benzylhexahydropyrrolo[3,4-c]pyrrol-2-yl)-(4,6-dimethylpyrimidin-5-yl)methanone

There total 5 articles about (5-benzylhexahydropyrrolo[3,4-c]pyrrol-2-yl)-(4,6-dimethylpyrimidin-5-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 172739-04-7
cis-3-benzyl-3,7-diazabicyclo[3.3.0]octane

: 157335-93-8
4,6-dimethylpyrimidine-5-carboxylic acid

: 872001-73-5
(5-benzylhexahydropyrrolo[3,4-c]pyrrol-2-yl)-(4,6-dimethylpyrimidin-5-yl)methanone

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

Reference yield:

: C₁₃H₁₄N₂O₂

: 872001-73-5
(5-benzylhexahydropyrrolo[3,4-c]pyrrol-2-yl)-(4,6-dimethylpyrimidin-5-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 50 °C / Reflux; Large scale reaction

2.1: potassium phosphate; dipotassium hydrogenphosphate / water; acetonitrile / 2 h / 0 °C / Large scale reaction

2.2: 10 °C / Large scale reaction

With potassium phosphate; dipotassium hydrogenphosphate; sodium bis(2-methoxyethoxy)aluminium dihydride; In water; toluene; acetonitrile;
DOI:10.1021/op100020z

Reference yield:

: 189348-38-7,1220514-64-6
2,5-dibenzyltetrahydropyrrolo[3,4-c]pyrrole-1,3-dione

: 872001-73-5
(5-benzylhexahydropyrrolo[3,4-c]pyrrol-2-yl)-(4,6-dimethylpyrimidin-5-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: palladium 10% on activated carbon; ammonium formate / methanol / 5 h / 60 °C / Large scale reaction

2.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 50 °C / Reflux; Large scale reaction

3.1: potassium phosphate; dipotassium hydrogenphosphate / water; acetonitrile / 2 h / 0 °C / Large scale reaction

3.2: 10 °C / Large scale reaction

With potassium phosphate; dipotassium hydrogenphosphate; palladium 10% on activated carbon; ammonium formate; sodium bis(2-methoxyethoxy)aluminium dihydride; In methanol; water; toluene; acetonitrile;
DOI:10.1021/op100020z