2-(3-bromophenyl)-5-(4-(tert-butyl)phenyl)-1,3,4-oxadiazole

Base Information

• Chemical Name: 2-(3-bromophenyl)-5-(4-(tert-butyl)phenyl)-1,3,4-oxadiazole
• CAS No.: 328285-14-9
• Molecular Formula: C₁₈H₁₇BrN₂O
• Molecular Weight: 357.25
• Mol file: 328285-14-9.mol

Synonyms:2-(3-bromophenyl)-5-(4-(tert-butyl)phenyl)-1,3,4-oxadiazole

Chemical Property of 2-(3-bromophenyl)-5-(4-(tert-butyl)phenyl)-1,3,4-oxadiazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3-bromophenyl)-5-(4-(tert-butyl)phenyl)-1,3,4-oxadiazole

There total 5 articles about 2-(3-bromophenyl)-5-(4-(tert-butyl)phenyl)-1,3,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

5-(3-bromo-phenyl)-1H-tetrazole (3440-99-1) + p-tert-butyl benzoyl chloride (1710-98-1) → 2-(3-bromophenyl)-5-(4-(tert-butyl)phenyl)-1,3,4-oxadiazole (328285-14-9)

Guidance literature:

With pyridine; at 120 ℃; for 24h;

DOI:10.1039/c2jm33376g

Reference yield: 68.0%

N-(4-tert-butylbenzoyl)-N'-(3-bromobenzoyl)hydrazide (415691-68-8) → 2-(3-bromophenyl)-5-(4-(tert-butyl)phenyl)-1,3,4-oxadiazole (328285-14-9)

Guidance literature:

With trichlorophosphate; at 100 ℃; for 5h;

DOI:10.1039/c6tc01108j

Reference yield:

3-bromobenzoyl chloride (1711-09-7) → 2-(3-bromophenyl)-5-(4-(tert-butyl)phenyl)-1,3,4-oxadiazole (328285-14-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1-methyl-pyrrolidin-2-one / 6 h / 20 °C / Inert atmosphere

2: trichlorophosphate / 5 h / 100 °C

With trichlorophosphate; In 1-methyl-pyrrolidin-2-one;

DOI:10.1039/c6tc01108j

upstream raw materials:

5-(3-bromo-phenyl)-1H-tetrazole

p-tert-butyl benzoyl chloride

3-cyanobromobenzene

4-tert-butylbenzoic acid hydrazide

Downstream raw materials:

tpOXD-mTP

2-(3-(anthracen-9-yl)phenyl)-5-(4-tert-butylphenyl)-1,3,4-oxadiazole