2H-Pyran-2-carboxylicacid,3,4-dihydro-4-oxo-,methylester,(2R)-(9CI)

Base Information

Chemical Name:2H-Pyran-2-carboxylicacid,3,4-dihydro-4-oxo-,methylester,(2R)-(9CI)
CAS No.:183013-60-7
Molecular Formula:C₇H₈O₄
Molecular Weight:156.138
Hs Code.:
Mol file:183013-60-7.mol

Synonyms:2H-Pyran-2-carboxylicacid, 3,4-dihydro-4-oxo-, methyl ester, (R)-

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Chemical Property of 2H-Pyran-2-carboxylicacid,3,4-dihydro-4-oxo-,methylester,(2R)-(9CI)

Chemical Property:

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Technology Process of 2H-Pyran-2-carboxylicacid,3,4-dihydro-4-oxo-,methylester,(2R)-(9CI)

There total 13 articles about 2H-Pyran-2-carboxylicacid,3,4-dihydro-4-oxo-,methylester,(2R)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.0%

: (S)-2,4,4-trimethoxy-6-(o-methoxyphenyl)tetrahydropyran

: 18107-18-1
diazomethyl-trimethyl-silane

: 157493-03-3,183013-60-7,333719-20-3
(S)-methyl 2,3-dihydro-4H-pyran-4-one-2-carboxylate

Guidance literature:: (S)-2,4,4-trimethoxy-6-(o-methoxyphenyl)tetrahydropyran; With ruthenium trichloride; sodium periodate; In tetrachloromethane; water; acetonitrile; at 20 ℃; for 4h;

diazomethyl-trimethyl-silane; With methanol; In diethyl ether; at 20 ℃;

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 12h;

Reference yield:

: 922-68-9
Methyl glyoxylate

: 71735-01-8
(E)-3-(tert-butyldimethylsilyloxy)-1-methoxy-1,3-butadiene

: 183013-60-7,333719-20-3
(2R)-2,3-dihydro-2-carbomethoxy-4H-pyran-4-one

: 157493-03-3,183013-60-7,333719-20-3
(S)-methyl 2,3-dihydro-4H-pyran-4-one-2-carboxylate

Guidance literature:: Methyl glyoxylate; (E)-3-(tert-butyldimethylsilyloxy)-1-methoxy-1,3-butadiene; (S,S)-(Bn-Phebox)RhCl₂(H₂O); In toluene; at -78 ℃; for 1h;

With trifluoroacetic acid; In toluene; at -78 - 0 ℃; Title compound not separated from byproducts;
DOI:10.1016/S0040-4020(00)01049-8

Reference yield:

: 922-68-9
Methyl glyoxylate

: 71735-01-8
(E)-3-(tert-butyldimethylsilyloxy)-1-methoxy-1,3-butadiene

: 183013-60-7,333719-20-3
(2R)-2,3-dihydro-2-carbomethoxy-4H-pyran-4-one

: 157493-03-3,183013-60-7,333719-20-3
(S)-methyl 2,3-dihydro-4H-pyran-4-one-2-carboxylate

Guidance literature:: Methyl glyoxylate; (E)-3-(tert-butyldimethylsilyloxy)-1-methoxy-1,3-butadiene; (S,S)-(Bn-Phebox)RhCl₂(H₂O); In toluene; at -78 ℃; for 1h;

With trifluoroacetic acid; In toluene; at -78 - 0 ℃; Title compound not separated from byproducts;
DOI:10.1016/S0040-4020(00)01049-8