922-68-9Relevant articles and documents
Indium-mediated diastereoselective allylation of N-tert-butanesulfinyl imines derived from α-ketoesters
Maciá, Edgar,Foubelo, Francisco,Yus, Miguel
, p. 6001 - 6010 (2016)
The indium-mediated allylation of α-aldimino and -ketimino esters 3 with allylic bromides proceeds with high diastereoselectivity to yield homoallylic α-amino ester derivatives 5, in both THF and water as solvents. The reactions are diastereospecific, the stereochemical outcome depending on the configuration of both the sulfur atom of the sulfinyl group and the C[dbnd]N double bond. Of particular interest are the reaction products using ethyl bromomethylacrylate as allylating reagent because amino diesters are obtained, which can be easily transformed into enantiomerically pure α-methylidene-γ-butyrolactams 6 with an alkoxycarbonyl group on the ring bearing the nitrogen atom.
An Economical Route to Lamivudine Featuring a Novel Strategy for Stereospecific Assembly
Abdiaj, Irini,Ahmad, Saeed,Burns, Justina M.,Gopalsamuthiram, Vijayagopal,Gupton, B. Frank,Krack, Rudy,McQuade, D. Tyler,Nelson, Ryan C.,Snead, David R.,Stringham, Rodger W.
supporting information, p. 1194 - 1198 (2020/07/15)
An economical synthesis of lamivudine was developed by employing a new method to establish the stereochemistry about the heterocyclic oxathiolane ring. Toward this end, an inexpensive and readily accessible lactic acid derivative served the dual purpose of activating the carbohydrate's anomeric center for N-glycosylation and transferring stereochemical information to the substrate simultaneously. Both enantiomers of the lactic acid derivative are available, and either β-enantiomer in this challenging class of 2′-deoxynucleoside active pharmaceutical ingredients can be formed.
Method for producing glyoxylate through oxidation of glycollate
-
Paragraph 0080; 0081; 0082; 0083; 0084; 0085; 0086-0131, (2017/12/30)
The invention relates to a method for producing glyoxylate through oxidation of glycollate. The invention mainly aims to overcome the problem of low yield of glyoxylate in the prior art. The method provided by the invention comprises a reaction step of contacting a nitrogen oxide and oxygen-containing gas with glycollate to produce glyoxylate. A catalyst used in the invention comprises the following components by weight: a) 0.5 to 30 parts of at least one active component selected from a group consisting of iron and iron oxides; b) 0 to 10 parts of an auxiliary agent which is at least one metal selected from a group consisting of group IA or group IIA elements or oxides thereof; and c) 70 to 99 parts of a carrier. With such a technical scheme, the above problem is overcome, and the method is applicable to industrial production of glyoxylate through oxidation of glycollate.
