(+/-)-(4-methyl-1-piperazinyl){2-[(trifluoromethyl)oxy]phenyl}acetic acid hydrochloride

Base Information

Chemical Name:(+/-)-(4-methyl-1-piperazinyl){2-[(trifluoromethyl)oxy]phenyl}acetic acid hydrochloride
CAS No.:1092477-39-8
Molecular Formula:C₁₄H₁₇F₃N₂O₃*ClH
Molecular Weight:354.757
Hs Code.:

Synonyms:(+/-)-(4-methyl-1-piperazinyl){2-[(trifluoromethyl)oxy]phenyl}acetic acid hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+/-)-(4-methyl-1-piperazinyl){2-[(trifluoromethyl)oxy]phenyl}acetic acid hydrochloride

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Technology Process of (+/-)-(4-methyl-1-piperazinyl){2-[(trifluoromethyl)oxy]phenyl}acetic acid hydrochloride

There total 1 articles about (+/-)-(4-methyl-1-piperazinyl){2-[(trifluoromethyl)oxy]phenyl}acetic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

: 109-01-3
1-methyl-piperazine

: 298-12-4
Glyoxilic acid

: 175676-65-0
2-trifluoromethoxyphenylboronic acid

: 1092477-39-8
(+/-)-(4-methyl-1-piperazinyl){2-[(trifluoromethyl)oxy]phenyl}acetic acid hydrochloride

Guidance literature:: In acetonitrile; for 24h; Heating / reflux;

Reference yield: 62.0%

: 886-35-1
3,5-bis(trifluoromethyl)phenylhydrazine

: 1092477-39-8
(+/-)-(4-methyl-1-piperazinyl){2-[(trifluoromethyl)oxy]phenyl}acetic acid hydrochloride

: 1092476-17-9
(+/-)-N'-[3,5-bis(trifluoromethyl)phenyl]-2-(4-methyl-1-piperazinyl)-2-{2-[(trifluoromethyl)oxy]phenyl}acetohydrazide

Guidance literature:: 3,5-bis(trifluoromethyl)phenylhydrazine; (+/-)-(4-methyl-1-piperazinyl){2-[(trifluoromethyl)oxy]phenyl}acetic acid hydrochloride; With benzotriazol-1-ol; In 1-methyl-pyrrolidin-2-one; dichloromethane; at 20 ℃;

With PS-Trisamine; PS-isocyanate; In 1-methyl-pyrrolidin-2-one; dichloromethane; at 20 ℃; Product distribution / selectivity;