4-{4-[((S)-6-Amino-2-tert-butoxycarbonylamino-hexanoylamino)-methyl]-benzyl}-benzoic acid methyl ester

Base Information

• Chemical Name: 4-{4-[((S)-6-Amino-2-tert-butoxycarbonylamino-hexanoylamino)-methyl]-benzyl}-benzoic acid methyl ester
• CAS No.: 162554-07-6
• Molecular Formula: C₂₇H₃₇N₃O₅
• Molecular Weight: 483.608
• Mol file: 162554-07-6.mol

Synonyms:4-{4-[((S)-6-Amino-2-tert-butoxycarbonylamino-hexanoylamino)-methyl]-benzyl}-benzoic acid methyl ester

Chemical Property of 4-{4-[((S)-6-Amino-2-tert-butoxycarbonylamino-hexanoylamino)-methyl]-benzyl}-benzoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-{4-[((S)-6-Amino-2-tert-butoxycarbonylamino-hexanoylamino)-methyl]-benzyl}-benzoic acid methyl ester

There total 7 articles about 4-{4-[((S)-6-Amino-2-tert-butoxycarbonylamino-hexanoylamino)-methyl]-benzyl}-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

4-{4-[((S)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-methyl]-benzyl}-benzoic acid methyl ester (183947-71-9) → 4-{4-[((S)-6-Amino-2-tert-butoxycarbonylamino-hexanoylamino)-methyl]-benzyl}-benzoic acid methyl ester (162554-07-6)

Guidance literature:

With hydrogen; palladium on activated charcoal;

DOI:10.1021/ja9607805

Reference yield:

Boc-Lys(Z)-OH (2389-45-9) → 4-{4-[((S)-6-Amino-2-tert-butoxycarbonylamino-hexanoylamino)-methyl]-benzyl}-benzoic acid methyl ester (162554-07-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 54 percent / HOBt, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide / tetrahydrofuran

2: 83 percent / H₂ / Pd/C

With hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In tetrahydrofuran;

DOI:10.1021/ja9607805

Reference yield:

4-(4-Aminomethyl-benzyl)-benzoic acid methyl ester; hydrochloride → 4-{4-[((S)-6-Amino-2-tert-butoxycarbonylamino-hexanoylamino)-methyl]-benzyl}-benzoic acid methyl ester (162554-07-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 54 percent / HOBt, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide / tetrahydrofuran

2: 83 percent / H₂ / Pd/C

With hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In tetrahydrofuran;

DOI:10.1021/ja9607805

upstream raw materials:

4-{4-[((S)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-methyl]-benzyl}-benzoic acid methyl ester

Boc-Lys(Z)-OH

Methyl 4-(bromomethyl)benzoate

4-cyanophenylboronic acid

Downstream raw materials:

C₅₅H₇₂N₆O₁₀S

4-{4-[((S)-2-tert-Butoxycarbonylamino-6-isothiocyanato-hexanoylamino)-methyl]-benzyl}-benzoic acid methyl ester

C₅₃H₆₈N₆O₁₀S