{5-[2-(2-Chloro-phenyl)-2,3-dihydro-benzo[b][1,4]thiazepin-4-yl]-6-hydroxy-3-methyl-benzofuran-2-yl}-phenyl-methanone

Base Information

• Chemical Name: {5-[2-(2-Chloro-phenyl)-2,3-dihydro-benzo[b][1,4]thiazepin-4-yl]-6-hydroxy-3-methyl-benzofuran-2-yl}-phenyl-methanone
• CAS No.: 198343-10-1
• Molecular Formula: C₃₁H₂₂ClNO₃S
• Molecular Weight: 524.04

Synonyms:{5-[2-(2-Chloro-phenyl)-2,3-dihydro-benzo[b][1,4]thiazepin-4-yl]-6-hydroxy-3-methyl-benzofuran-2-yl}-phenyl-methanone

Chemical Property of {5-[2-(2-Chloro-phenyl)-2,3-dihydro-benzo[b][1,4]thiazepin-4-yl]-6-hydroxy-3-methyl-benzofuran-2-yl}-phenyl-methanone

Chemical Property:

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Technology Process of {5-[2-(2-Chloro-phenyl)-2,3-dihydro-benzo[b][1,4]thiazepin-4-yl]-6-hydroxy-3-methyl-benzofuran-2-yl}-phenyl-methanone

There total 4 articles about {5-[2-(2-Chloro-phenyl)-2,3-dihydro-benzo[b][1,4]thiazepin-4-yl]-6-hydroxy-3-methyl-benzofuran-2-yl}-phenyl-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-amino-benzenethiol (137-07-5) + (E)-1-(2-Benzoyl-6-hydroxy-3-methyl-benzofuran-5-yl)-3-(2-chloro-phenyl)-propenone (233669-44-8) → {5-[2-(2-Chloro-phenyl)-2,3-dihydro-benzo[b][1,4]thiazepin-4-yl]-6-hydroxy-3-methyl-benzofuran-2-yl}-phenyl-methanone (198343-10-1)

Guidance literature:

With silica gel; In ethanol; for 0.0833333h; Wavelength; Reagent/catalyst; Solvent; Microwave irradiation; Green chemistry;

Reference yield:

1-(5-acetyl-2,4-dihydroxyphenyl)-1-ethanone (2161-85-5) → {5-[2-(2-Chloro-phenyl)-2,3-dihydro-benzo[b][1,4]thiazepin-4-yl]-6-hydroxy-3-methyl-benzofuran-2-yl}-phenyl-methanone (198343-10-1)

Guidance literature:

Multi-step reaction with 3 steps

1: K₂CO₃ / acetone / 6 h / Heating

2: aq. KOH / ethanol / 24 h / 20 °C

3: AcOH / 4 h / Heating

With potassium hydroxide; potassium carbonate; acetic acid; In ethanol; acetone; 1: Condensation / 2: Condensation / 3: Cyclization;

DOI:10.1080/00397910008087316

Reference yield:

α-bromoacetophenone (70-11-1) → {5-[2-(2-Chloro-phenyl)-2,3-dihydro-benzo[b][1,4]thiazepin-4-yl]-6-hydroxy-3-methyl-benzofuran-2-yl}-phenyl-methanone (198343-10-1)

Guidance literature:

Multi-step reaction with 3 steps

1: K₂CO₃ / acetone / 6 h / Heating

2: aq. KOH / ethanol / 24 h / 20 °C

3: AcOH / 4 h / Heating

With potassium hydroxide; potassium carbonate; acetic acid; In ethanol; acetone; 1: Condensation / 2: Condensation / 3: Cyclization;

DOI:10.1080/00397910008087316

upstream raw materials:

2-amino-benzenethiol

(E)-1-(2-Benzoyl-6-hydroxy-3-methyl-benzofuran-5-yl)-3-(2-chloro-phenyl)-propenone

1-(5-acetyl-2,4-dihydroxyphenyl)-1-ethanone

α-bromoacetophenone

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