6-(p-tolyl)-4-vinylthieno[2,3-d]pyrimidine

Base Information

Chemical Name:6-(p-tolyl)-4-vinylthieno[2,3-d]pyrimidine
CAS No.:1610772-20-7
Molecular Formula:C₁₅H₁₂N₂S
Molecular Weight:252.34
Hs Code.:

Synonyms:6-(p-tolyl)-4-vinylthieno[2,3-d]pyrimidine

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Chemical Property of 6-(p-tolyl)-4-vinylthieno[2,3-d]pyrimidine

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Technology Process of 6-(p-tolyl)-4-vinylthieno[2,3-d]pyrimidine

There total 5 articles about 6-(p-tolyl)-4-vinylthieno[2,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1610772-26-3
4-chloro-6-(p-tolyl)thieno[2,3-d]pyrimidine

: potassium vinyltrifluoroborate

: 1610772-20-7
6-(p-tolyl)-4-vinylthieno[2,3-d]pyrimidine

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; triethylamine; In water; isopropyl alcohol; at 100 ℃; for 1h; Inert atmosphere; Sealed tube;
DOI:10.1021/jm500629e

Reference yield:

: 5720-05-8
4-methylphenylboronic acid

: 1610772-20-7
6-(p-tolyl)-4-vinylthieno[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 1 h / 100 °C

2: triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; isopropyl alcohol / 1 h / 100 °C / Inert atmosphere; Sealed tube

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; triethylamine; In 1,4-dioxane; water; isopropyl alcohol; 1: |Suzuki Coupling;
DOI:10.1021/jm500629e

Reference yield:

: 14080-50-3
thieno[2,3-d]pyrimidin-4(3H)one

: 1610772-20-7
6-(p-tolyl)-4-vinylthieno[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1: bromine; acetic acid / 80 °C

2: trichlorophosphate / 95 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 1 h / 100 °C

4: triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; isopropyl alcohol / 1 h / 100 °C / Inert atmosphere; Sealed tube

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; bromine; potassium carbonate; acetic acid; triethylamine; trichlorophosphate; In 1,4-dioxane; water; isopropyl alcohol; 3: |Suzuki Coupling;
DOI:10.1021/jm500629e